SJA710-6 | CAS#1397255-09-2 | Hepatic Differentiation Inducer

MedKoo Cat#: 555867 | Name: SJA710-6

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SJA710-6 is a hepatic differentiation inducer.

Chemical Structure

SJA710-6

CAS#1397255-09-2

Theoretical Analysis

MedKoo Cat#: 555867

Name: SJA710-6

CAS#: 1397255-09-2

Chemical Formula: C22H20BrFN4

Exact Mass: 438.0855

Molecular Weight: 439.33

Elemental Analysis: C, 60.15; H, 4.59; Br, 18.19; F, 4.32; N, 12.75

Price and Availability

Size	Price	Availability
50mg	USD 350.00	2 Weeks
100mg	USD 550.00	2 Weeks
200mg	USD 950.00	2 Weeks
500mg	USD 1,650.00	2 Weeks
1g	USD 2,650.00	2 Weeks
2g	USD 4,650.00	2 Weeks
5g	USD 6,950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

SJA710-6; SJA-710-6; SJA 710-6; SJA7106; SJA-7106; SJA 7106;

IUPAC/Chemical Name

2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine

InChi Key

RPNQWWSSADJSGS-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H20BrFN4/c1-2-13-28-21(16-5-7-17(23)8-6-16)26-19-11-12-20(27-22(19)28)25-14-15-3-9-18(24)10-4-15/h3-12H,2,13-14H2,1H3,(H,25,27)

SMILES Code

CCCN1C(C2=CC=C(Br)C=C2)=NC3=CC=C(NCC4=CC=C(F)C=C4)N=C31

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Mesenchymal stem cells (MSCs) are capable of self-renewal and multilineage differentiation. A periodic acid-Schiff (PAS) stain-based assay was developed to screen for small-molecule inducers of hepatic differentiation of bone marrow MSCs.

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SJA710-6 selectively differentiates MSCs toward hepatocyte-like cells.

In vitro activity:

SJA710-6 was able to induce the differentiation of rMSCs toward hepatocyte-like cells in vitro. rMSCs treated with SJA710-6 had typical morphological and functional characteristics of hepatic cells, including glycogen storage, urea secretion, uptake of low density lipoprotein (LDL) and expression of hepatocyte-specific genes and proteins. Reference: ChemMedChem. 2012 Aug;7(8):1447-52. https://pubmed.ncbi.nlm.nih.gov/22715131/

In vivo activity:

SJA6017 may have potential in spinal cord injury treatment. In a rat spinal cord injury model, SJA6017 reduced apoptotic cell death, preserved spinal cord tissue and improved functional outcome. SJA6017 treated rats had significantly reduced tissue injury and had ameliorated recovery of limb function. Reference: J Clin Neurosci. 2008 Oct;15(10):1130-6. https://pubmed.ncbi.nlm.nih.gov/18656362/

	Solvent	mg/mL	mM
Solubility
	DMSO	250.0	569.06

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 439.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.

In vitro protocol:

In vivo protocol:

To be determined

Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.

View History

Eucarvone

MedKoo CAT#: 149220

CAS#: 503-93-5