VULM 1457 is a potent inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol metabolism. By inhibiting ACAT, VULM 1457 decreases cholesterol levels in the plasma and liver, demonstrating significant hypolipidemic activity. Additionally, it has been shown to reduce the production and secretion of adrenomedullin (AM) and down-regulate AM receptors in human hepatoblastic cells.
MedKoo Cat#: 574933
Name: VULM-1457
CAS#: 228544-65-8
Chemical Formula: C25H27N3O3S
Exact Mass: 449.1773
Molecular Weight: 449.57
Elemental Analysis: C, 66.79; H, 6.05; N, 9.35; O, 10.68; S, 7.13
The following data is based on the product molecular weight 449.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
