BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and angiogenesis. BX-320 inhibits PDK1 enzyme activity in a kinase assay with an IC₅₀ of 30 nM. BX-320 blocks the growth of MDA-453, U87-MG and PC-3 cells in soft agar with IC₅₀ values of 0.093 μM, 0.3 μM and 0.4 μM respectively. BX-320 inhibits the growth of LOX melanoma tumors in mice models.
MedKoo Cat#: 412192
Name: BX-320
CAS#: 702676-93-5
Chemical Formula: C23H31BrN8O3
Exact Mass: 546.1702
Molecular Weight: 547.46
Elemental Analysis: C, 50.46; H, 5.71; Br, 14.60; N, 20.47; O, 8.77
The following data is based on the product molecular weight 547.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
