MedKoo Cat#: 412184 | Name: BW 737C89

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BW 737C89 is a highly potent dopamine D1 receptor antagonist; BW-737C is the (S)-isomer; BW-736C is the (R)-isomer.

Chemical Structure

 BW 737C89
BW 737C89
CAS#139485-39-5

Theoretical Analysis

MedKoo Cat#: 412184

Name: BW 737C89

CAS#: 139485-39-5

Chemical Formula: C22H28ClNO3

Exact Mass: 389.1758

Molecular Weight: 389.92

Elemental Analysis: C, 67.77; H, 7.24; Cl, 9.09; N, 3.59; O, 12.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
BW 737C89; BW736C; BW-736C; BW 736C; BW737C; BW-737C; BW 737C
IUPAC/Chemical Name
7-Isoquinolinol, 6-chloro-1-((2,5-dimethoxy-4-propylphenyl)methyl)-1,2,3,4-tetrahydro-2-methyl-, (S)-
InChi Key
MGBDPWBQYMLBMQ-IBGZPJMESA-N
InChi Code
InChI=1S/C22H28ClNO3/c1-5-6-15-11-22(27-4)16(12-21(15)26-3)10-19-17-13-20(25)18(23)9-14(17)7-8-24(19)2/h9,11-13,19,25H,5-8,10H2,1-4H3/t19-/m0/s1
SMILES Code
OC1=CC2=C(C=C1Cl)CCN(C)[C@H]2CC3=CC(OC)=C(CCC)C=C3OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 389.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Deveney AM, Waddington JL. Evidence for dopamine 'D1-like' receptor subtypes in the behavioural effects of two new selective antagonists, LY 270411 and BW 737C. Eur J Pharmacol. 1996 Dec 19;317(2-3):175-81. doi: 10.1016/s0014-2999(96)00717-0. PMID: 8997598. 2: Deveney AM, Waddington JL. Pharmacological characterization of behavioural responses to SK&F 83959 in relation to 'D1-like' dopamine receptors not linked to adenylyl cyclase. Br J Pharmacol. 1995 Oct;116(3):2120-6. doi: 10.1111/j.1476-5381.1995.tb16420.x. PMID: 8640354; PMCID: PMC1908936. 3: Rosenzweig-Lipson S, Bergman J. Catalepsy-associated behavior induced by dopamine D1 receptor antagonists and partial dopamine D1 receptor agonists in squirrel monkeys. Eur J Pharmacol. 1994 Aug 1;260(2-3):237-41. doi: 10.1016/0014-2999(94)90343-3. PMID: 7988649. 4: Daly SA, Waddington JL. Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other "D-2-like" agonists. Neuropharmacology. 1993 May;32(5):509-10. doi: 10.1016/0028-3908(93)90177-5. PMID: 8321432. 5: Daly SA, Waddington JL. Behavioural evidence for "D-1-like" dopamine receptor subtypes in rat brain using the new isochroman agonist A 68930 and isoquinoline antagonist BW 737C. Psychopharmacology (Berl). 1993;113(1):45-50. doi: 10.1007/BF02244332. PMID: 7862827. 6: Daly SA, Waddington JL. Two directions of dopamine D1/D2 receptor interaction in studies of behavioural regulation: a finding generic to four new, selective dopamine D1 receptor antagonists. Eur J Pharmacol. 1992 Mar 24;213(2):251-8. doi: 10.1016/0014-2999(92)90689-2. PMID: 1387846. 7: Riddall DR. A comparison of the selectivities of SCH 23390 with BW737C89 for D1, D2 and 5-HT2 binding sites both in vitro and in vivo. Eur J Pharmacol. 1992 Jan 21;210(3):279-84. doi: 10.1016/0014-2999(92)90416-2. PMID: 1351844.