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MedKoo Cat#: 463163 | Name: GalNAc
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

N-acetyl-D-Galactosamine (GalNAc) is an amino sugar derivative of galactose and a component of O-GalNAc glycans. It is transferred from UDP-GalNAc to the hydroxy group of protein serine or threonine residues by polypeptide GalNAc transferase, forming the Tn antigen, during the first step of mucin-type O-glycosylation. GalNAc has been used as a targeting moiety for liver-targeted delivery of oligonucleotides.

Chemical Structure

GalNAc
GalNAc
CAS#1811-31-0

Theoretical Analysis

MedKoo Cat#: 463163

Name: GalNAc

CAS#: 1811-31-0

Chemical Formula: C8H15NO6

Exact Mass: 221.0899

Molecular Weight: 221.21

Elemental Analysis: C, 43.44; H, 6.84; N, 6.33; O, 43.40

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
2g USD 550.00 2 Weeks
5g USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
GalNAc; N-Acetylgalactosamine; N-acetyl-D-Galactosamine; D-N-Acetylgalactosamine;
IUPAC/Chemical Name
N-((2R,3R,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)acetamide
InChi Key
MBLBDJOUHNCFQT-OSMVPFSASA-N
InChi Code
InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8-/m0/s1
SMILES Code
O=C[C@@H]([C@H]([C@H]([C@@H](CO)O)O)O)NC(C)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 221.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang S, Wang Y, Mann M, Wang Q, Tian E, Zhang L, Cipollo JF, Ten Hagen KG, Tabak LA. Improved online LC-MS/MS identification of O-glycosites by EThcD fragmentation, chemoenzymatic reaction, and SPE enrichment. Glycoconj J. 2020 Oct 17. doi: 10.1007/s10719-020-09952-w. Epub ahead of print. PMID: 33068214. 2: Badri P, Jiang X, Borodovsky A, Najafian N, Kim J, Clausen VA, Goel V, Habtemariam B, Robbie GJ. Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria. Clin Pharmacokinet. 2020 Oct 13. doi: 10.1007/s40262-020-00940-9. Epub ahead of print. PMID: 33047216. 3: Yamagishi Y, Kuwahara M, Suzuki H, Sonoo M, Kuwabara S, Yokota T, Nomura K, Chiba A, Kaji R, Kanda T, Kaida KI, Mutoh T, Yamasaki R, Takashima H, Matsui M, Nishiyama K, Sobue G, Kusunoki S. Serum IgG anti-GD1a antibody and mEGOS predict outcome in Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry. 2020 Oct 11:jnnp-2020-323960. doi: 10.1136/jnnp-2020-323960. Epub ahead of print. PMID: 33041261. 4: Napoletano C, Steentoff C, Battisti F, Ye Z, Rahimi H, Zizzari IG, Dionisi M, Cerbelli B, Tomao F, French D, d'Amati G, Panici PB, Vakhrushev S, Clausen H, Nuti M, Rughetti A. Investigating Patterns of Immune Interaction in Ovarian Cancer: Probing the O-glycoproteome by the Macrophage Galactose-Like C-type Lectin (MGL). Cancers (Basel). 2020 Oct 1;12(10):E2841. doi: 10.3390/cancers12102841. PMID: 33019700. 5: Li X, Zhang Y, Zhang M, Wang Y. GALNT2 regulates ANGPTL3 cleavage in cells and in vivo of mice. Sci Rep. 2020 Sep 30;10(1):16168. doi: 10.1038/s41598-020-73388-3. PMID: 32999434; PMCID: PMC7527996. 6: Debets MF, Tastan OY, Wisnovsky SP, Malaker SA, Angelis N, Moeckl LKR, Choi J, Flynn H, Wagner LJS, Bineva-Todd G, Antonopoulos A, Cioce A, Browne WM, Li Z, Briggs DC, Douglas HL, Hess GT, Agbay AJ, Roustan C, Kjaer S, Haslam SM, Snijders AP, Bassik MC, Moerner WE, Li VSW, Bertozzi CR, Schumann B. Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25293-25301. doi: 10.1073/pnas.2007297117. Epub 2020 Sep 28. PMID: 32989128. 7: Pyra A, Filik K, Szermer-Olearnik B, Czarny A, Brzozowska E. New Insights on the Feature and Function of Tail Tubular Protein B and Tail Fiber Protein of the Lytic Bacteriophage φYeO3-12 Specific for Yersinia enterocolitica Serotype O:3. Molecules. 2020 Sep 24;25(19):E4392. doi: 10.3390/molecules25194392. PMID: 32987777. 8: Walimbe AS, Okuma H, Joseph S, Yang T, Yonekawa T, Hord JM, Venzke D, Anderson ME, Torelli S, Manzur A, Devereaux M, Cuellar M, Prouty S, Ocampo Landa S, Yu L, Xiao J, Dixon JE, Muntoni F, Campbell KP. POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan. Elife. 2020 Sep 25;9:e61388. doi: 10.7554/eLife.61388. PMID: 32975514; PMCID: PMC7556876. 9: Xiong M, Zhao J, Huang T, Wang W, Wang L, Zhao Z, Li X, Zhou J, Xiao X, Pan Y, Lin J, Li Y. Molecular Characteristics, Virulence Gene and Wall Teichoic Acid Glycosyltransferase Profiles of Staphylococcus aureus: A Multicenter Study in China. Front Microbiol. 2020 Aug 19;11:2013. doi: 10.3389/fmicb.2020.02013. PMID: 32973729; PMCID: PMC7466653. 10: Pecori F, Akimoto Y, Hanamatsu H, Furukawa JI, Shinohara Y, Ikehara Y, Nishihara S. Mucin-type O-glycosylation controls pluripotency in mouse embryonic stem cells via Wnt receptor endocytosis. J Cell Sci. 2020 Sep 24:jcs.245845. doi: 10.1242/jcs.245845. Epub ahead of print. PMID: 32973111. 11: She YM, Tam RY, Li X, Rosu-Myles M, Sauvé S. Resolving Isomeric Structures of Native Glycans by Nanoflow Porous Graphitized Carbon Chromatography-Mass Spectrometry. Anal Chem. 2020 Oct 6. doi: 10.1021/acs.analchem.0c02951. Epub ahead of print. PMID: 32960038. 12: Srivastava AD, Unione L, Wolfert MA, Valverde P, Arda A, Jiménez-Barbero J, Boons GJ. Mono- and Di-Fucosylated Glycans of the Parasitic Worm S. mansoni are Recognized Differently by the Innate Immune Receptor DC-SIGN. Chemistry. 2020 Jul 6. doi: 10.1002/chem.202002619. Epub ahead of print. PMID: 32957164. 13: Gauthier L, Chevallet M, Bulteau F, Thépaut M, Delangle P, Fieschi F, Vivès C, Texier I, Deniaud A, Gateau C. Lectin recognition and hepatocyte endocytosis of GalNAc-decorated nanostructured lipid carriers. J Drug Target. 2020 Oct 2:1-9. doi: 10.1080/1061186X.2020.1806286. Epub ahead of print. PMID: 32936032. 14: Cao R, Zhang TC, Chen YR, Cao C, Chen H, Huang YF, Fujita M, Liu L, Voglmeir J. Aberration of Serum and Tissue N-Glycans in Mouse β1,4-GalT1 Y286L Mutant Variants. Glycoconj J. 2020 Sep 14. doi: 10.1007/s10719-020-09946-8. Epub ahead of print. PMID: 32926333. 15: Liu J, Cooley BC, Akinc A, Butler J, Borodovsky A. Knockdown of liver- derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function. Thromb Res. 2020 Aug 28;196:200-205. doi: 10.1016/j.thromres.2020.08.040. Epub ahead of print. PMID: 32896690. 16: Giorgi ME, Lederkremer RM. The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose. Molecules. 2020 Aug 27;25(17):3913. doi: 10.3390/molecules25173913. PMID: 32867240; PMCID: PMC7504415. 17: Zhou H, Guan Y, Feng M, Fu Y, Tachibana H, Cheng X. Evaluation on Elongation Factor 1 Alpha of Entamoeba histolytica Interaction with the Intermediate Subunit of the Gal/GalNAc Lectin and Actin in Phagocytosis. Pathogens. 2020 Aug 27;9(9):E702. doi: 10.3390/pathogens9090702. PMID: 32867020. 18: Matsui T, Komamoto K, Igarashi H, Kurohmaru M. Species-specific and heterogeneous distribution of sialoglycoconjugates in the primary olfactory center of three species of Asian salamanders (Cynops). Tissue Cell. 2020 Aug 19;67:101428. doi: 10.1016/j.tice.2020.101428. Epub ahead of print. PMID: 32858481. 19: Gao N, Chen R, Mou R, Xiang J, Zhou K, Li Z, Zhao J. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata. Int J Biol Macromol. 2020 Aug 21:S0141-8130(20)34243-4. doi: 10.1016/j.ijbiomac.2020.08.150. Epub ahead of print. PMID: 32835799. 20: Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, Tebas P, O'Doherty U, Tateno H, Liu Q, Betts MR, Montaner LJ, Abdel-Mohsen M. Interferon-α alters host glycosylation machinery during treated HIV infection. EBioMedicine. 2020 Sep;59:102945. doi: 10.1016/j.ebiom.2020.102945. Epub 2020 Aug 19. PMID: 32827942; PMCID: PMC7452630.