TMPH hydrochloride, known chemically as 2,2,6,6-tetramethylpiperidin-4-yl heptanoate hydrochloride, is a potent non-competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). It exhibits long-lasting inhibition of nAChRs formed by combinations of α3, α4, β2, and β4 subunits, while displaying minimal effects on muscle-type (α1β1γδ) or α7 receptors. This compound has been utilized in studies to mitigate the seizure-inducing effects of levamisole without inducing behavioral changes in animal models.
MedKoo Cat#: 574908
Name: TMPH hydrochloride
CAS#: 849461-91-2
Chemical Formula: C16H31NO2
Exact Mass: 269.2355
Molecular Weight: 269.43
Elemental Analysis: C, 71.33; H, 11.60; N, 5.20; O, 11.88
The following data is based on the product molecular weight 269.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
