Doxy-Myr is a Myristoyl Amide Derivative of Doxycycline, which potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis. Doxy-Myr is >5-fold more potent than Doxycycline, as it appears to be better retained in cells, within a peri-nuclear membranous compartment. Moreover, Doxy-Myr did not affect the viability of the total MCF7 cancer cell population or normal fibroblasts grown as 2D-monolayers, showing remarkable selectivity for CSCs. Doxy-Myr can effectively minimize the risk of driving antibiotic resistance.
MedKoo Cat#: 207149
Name: Doxy-Myr
CAS#: 2446010-87-1
Chemical Formula: C36H51N3O9
Exact Mass: 669.3625
Molecular Weight: 669.82
Elemental Analysis: C, 64.55; H, 7.67; N, 6.27; O, 21.50
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 669.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
