Synonym
Camphorataanhydride A; Antrodin A; AdA;
IUPAC/Chemical Name
2,5-Furandione, 3-(4-((3-methyl-2-butenyl)oxy)phenyl)-4-(2-methylpropyl)-
InChi Key
ZXIUCXGVUOQMSH-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22O4/c1-12(2)9-10-22-15-7-5-14(6-8-15)17-16(11-13(3)4)18(20)23-19(17)21/h5-9,13H,10-11H2,1-4H3
SMILES Code
O=C(C(C1=CC=C(OC/C=C(C)/C)C=C1)=C2CC(C)C)OC2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be dtermined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Antrodin A is one of the main active ingredients in the solid-state fermented A. camphorate mycelium.
In vitro activity:
Crude ethanol extracts and isolated constituents showed inhibition of HSV replication at a very low concentration. Fraction A and antrodin A showed viral inhibitory effect with reduction of viral cell-to-cell spread.
Reference: Antivir Ther. 2016;21(5):377-83. https://pubmed.ncbi.nlm.nih.gov/26313544/
In vivo activity:
In acute alcoholic liver injury mice, AdA ameliorated alcoholic exposure-induced hepatic lipid deposition (TC and TG), oxidative stress (MDA), inflammation (TNF-α, IL-1β, IL-6, IL-17 and IFN-γ), and liver damage via modulating microbiome and metabolomic responses.
Reference: Food Funct. 2021 Apr 7;12(7):2925-2937. https://pubmed.ncbi.nlm.nih.gov/33720247/
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
100.0 |
318.09 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
314.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. He YC, Lu ZH, Shi P, Hao JC, Zhao ZJ, Xie HT, Mao P, Chen SJ. Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia. Antivir Ther. 2016;21(5):377-83. doi: 10.3851/IMP2988. Epub 2015 Aug 27. PMID: 26313544.
2. Yi Z , Liu X , Liang L , Wang G , Xiong Z , Zhang H , Song X , Ai L , Xia Y . Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake. Food Funct. 2021 Apr 7;12(7):2925-2937. doi: 10.1039/d0fo03345f. Epub 2021 Mar 15. PMID: 33720247.
3. Yi ZW, Xia YJ, Liu XF, Wang GQ, Xiong ZQ, Ai LZ. Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice. J Ethnopharmacol. 2020 May 23;254:112681. doi: 10.1016/j.jep.2020.112681. Epub 2020 Feb 19. PMID: 32087320.
In vitro protocol:
1. He YC, Lu ZH, Shi P, Hao JC, Zhao ZJ, Xie HT, Mao P, Chen SJ. Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia. Antivir Ther. 2016;21(5):377-83. doi: 10.3851/IMP2988. Epub 2015 Aug 27. PMID: 26313544.
In vivo protocol:
1. Yi Z , Liu X , Liang L , Wang G , Xiong Z , Zhang H , Song X , Ai L , Xia Y . Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake. Food Funct. 2021 Apr 7;12(7):2925-2937. doi: 10.1039/d0fo03345f. Epub 2021 Mar 15. PMID: 33720247.
2. Yi ZW, Xia YJ, Liu XF, Wang GQ, Xiong ZQ, Ai LZ. Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice. J Ethnopharmacol. 2020 May 23;254:112681. doi: 10.1016/j.jep.2020.112681. Epub 2020 Feb 19. PMID: 32087320.
1: Yi Z , Liu X , Liang L , Wang G , Xiong Z , Zhang H , Song X , Ai L , Xia Y . Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake. Food Funct. 2021 Apr 7;12(7):2925-2937. doi: 10.1039/d0fo03345f. Epub 2021 Mar 15. PMID: 33720247.
2: Yi ZW, Xia YJ, Liu XF, Wang GQ, Xiong ZQ, Ai LZ. Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice. J Ethnopharmacol. 2020 May 23;254:112681. doi: 10.1016/j.jep.2020.112681. Epub 2020 Feb 19. PMID: 32087320.
3: Xie JQ, Chen YC, Sun ZH, Liu HX, Li SN, Li HH, Gao XX, Zhang WM. [Sesquiterpenoids of endophytic fungus Cerrena sp. from Pogostemon cablin and their cytotoxic activities]. Zhongguo Zhong Yao Za Zhi. 2017 May;42(9):1693-1698. Chinese. doi: 10.19540/j.cnki.cjcmm.20170224.009. PMID: 29082691.
4: He YC, Lu ZH, Shi P, Hao JC, Zhao ZJ, Xie HT, Mao P, Chen SJ. Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia. Antivir Ther. 2016;21(5):377-83. doi: 10.3851/IMP2988. Epub 2015 Aug 27. PMID: 26313544.
5: Phuong do T, Ma CM, Hattori M, Jin JS. Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease. Phytother Res. 2009 Apr;23(4):582-4. doi: 10.1002/ptr.2657. PMID: 19003946.
