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MedKoo Cat#: 412133 | Name: Blp 1654

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Blp 1654 is a new semisynthetic penicillin that possesses broad spectrum antimicrobial activity against many gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.

Chemical Structure

Blp 1654
Blp 1654
CAS#28889-87-4

Theoretical Analysis

MedKoo Cat#: 412133

Name: Blp 1654

CAS#: 28889-87-4

Chemical Formula: C18H22N6O5S

Exact Mass: 434.1372

Molecular Weight: 434.47

Elemental Analysis: C, 49.76; H, 5.10; N, 19.34; O, 18.41; S, 7.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Blp 1654; Blp-1654; Blp1654; BL-P1654: BLP1654; BL P1654
IUPAC/Chemical Name
(2S-(2alpha,5alpha,6beta(S*)))-6-((((((Aminoiminomethyl)amino)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
InChi Key
GIPLLNWRTXVAHM-UWFZAAFLSA-N
InChi Code
InChI=1S/C18H22N6O5S/c1-18(2)11(15(27)28)24-13(26)10(14(24)30-18)21-12(25)9(8-6-4-3-5-7-8)22-17(29)23-16(19)20/h3-7,9-11,14H,1-2H3,(H,21,25)(H,27,28)(H5,19,20,22,23,29)/t9?,10-,11+,14-/m1/s1
SMILES Code
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C(NC(NC(N)=N)=O)C3=CC=CC=C3)=O)N1C2=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nouws JF, Ziv G, Van Ginneken CA, Vree TB. Clinical pharmacokinetics of carbenicillin, carfecillin, ticarcillin and BL-P 1654 in dairy cows. J Vet Pharmacol Ther. 1984 Mar;7(1):35-43. doi: 10.1111/j.1365-2885.1984.tb00876.x. PMID: 6323731. 2: Cagle GD, Schlech BA. Evaluation of BL-P1654: a semisynthetic penicillin as a topical ocular therapy. Cornea. 1984;3(1):27-32. PMID: 6100241. 3: Stewart D, Bodey GP. Azlocillin: in vitro studies of a new semisynthetic penicillin. Antimicrob Agents Chemother. 1977 May;11(5):865-70. doi: 10.1128/aac.11.5.865. PMID: 18083; PMCID: PMC352088. 4: Sutter VL, Finegold SM. Susceptibility of anaerobic bacteria to 23 antimicrobial agents. Antimicrob Agents Chemother. 1976 Oct;10(4):736-52. doi: 10.1128/aac.10.4.736. PMID: 984809; PMCID: PMC429823. 5: Eickhoff TC, Ehret JM. Comparative activity in vitro of ticarcillin, BL-P1654, and carbenicillin. Antimicrob Agents Chemother. 1976 Aug;10(2):241-4. doi: 10.1128/aac.10.2.241. PMID: 984764; PMCID: PMC429728. 6: Bodey GP, Rodriguez V, Weaver S. Pirbenicillin, a new semisynthetic penicillin with broad-spectrum activity. Antimicrob Agents Chemother. 1976 Apr;9(4):668-74. doi: 10.1128/aac.9.4.668. PMID: 817665; PMCID: PMC429596. 7: Ellis LF, Herron DK, Preston DA, Simmons LK, Schlegel RA. Evaluation of antibiotic efficacy using electron microscopy: morphological effects of guanylureido cephalosporin, chlorobenzoylureido cephalosporin, BL-P1654, and carbenicillin on Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1976 Feb;9(2):334-42. doi: 10.1128/aac.9.2.334. PMID: 817659; PMCID: PMC429523. 8: Wald ER, Standiford HC, Tatem BA, Calia FM, Hornick RB. BL-P1654, ticarcillin, and carbenicillin: in vitro comparison alone and in combination with gentamicin against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1975 Mar;7(3):336-40. doi: 10.1128/aac.7.3.336. PMID: 806263; PMCID: PMC429136. 9: Kurtz S, Holmes K, Turck M. Disparity between inhibitory and killing effects of BL-P1654. Antimicrob Agents Chemother. 1975 Feb;7(2):215-8. doi: 10.1128/aac.7.2.215. PMID: 1137373; PMCID: PMC429106. 10: Clarke JT, Libke RD, Ralph ED, Luthy RP, Kirby WM. Human pharmacokinetics of BL-P1654 compared with ampicillin. Antimicrob Agents Chemother. 1974 Dec;6(6):729-33. doi: 10.1128/aac.6.6.729. PMID: 4455125; PMCID: PMC444727. 11: Overturf GD, Ressler R, Wilkins J. Comparative in vitro evaluation of BL-P1654 and carbenicillin against Pseudomonas. Antimicrob Agents Chemother. 1974 Nov;6(5):643-6. doi: 10.1128/aac.6.5.643. PMID: 15825320; PMCID: PMC444707. 12: Bodey GP, Horikoshi N, Rodriguez V. Human pharmacology of 6-[D-alpha-(3-guanylureido)-phenylacetamido]-penicillanic acid (BL-P1654). Antimicrob Agents Chemother. 1974 Apr;5(4):366-70. doi: 10.1128/aac.5.4.366. PMID: 15825389; PMCID: PMC428976. 13: Adler JL, Finland M. Susceptibility of recent isolates of Pseudomonas aeruginosa to gentamicin, polymyxin, and five penicillins, with observations on the pyocin and immunotypes of the strains. Appl Microbiol. 1971 Nov;22(5):870-5. PMID: 4332044; PMCID: PMC376437.