Synonym
COR659; COR 659; COR-659;
IUPAC/Chemical Name
methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate
InChi Key
AAFLALGGEYRGTR-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H16ClNO3S/c1-4-12-9(2)22-15(13(12)16(20)21-3)18-14(19)10-5-7-11(17)8-6-10/h5-8H,4H2,1-3H3,(H,18,19)
SMILES Code
ClC1=CC=C(C(NC2=C(C(OC)=O)C(CC)=C(C)S2)=O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
337.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ferlenghi F, Maccioni P, Mugnaini C, Brizzi A, Fara F, Mostallino R, Castelli MP, Colombo G, Mor M, Vacondio F, Corelli F. The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci. 2020 Sep 12;155:105544. doi: 10.1016/j.ejps.2020.105544. Epub ahead of print. PMID: 32927068.
2: Maccioni P, Colombo G, Lorrai I, Fara F, Carai MAM, Gessa GL, Brizzi A, Mugnaini C, Corelli F. Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues. Alcohol. 2019 Mar;75:55-66. doi: 10.1016/j.alcohol.2018.05.007. Epub 2018 May 17. PMID: 30445248.
3: Maccioni P, Colombo G, Lorrai I, Zaru A, Carai MAM, Gessa GL, Brizzi A, Mugnaini C, Corelli F. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543. doi: 10.1007/s00213-017-4644-3. Epub 2017 May 24. PMID: 28536867.
