MedKoo Cat#: 574898 | Name: TC-N 1752
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-N 1752 is a human NaV channel inhibitor that also inhibits tetrodotoxin-sensitive sodium channels.

Chemical Structure

TC-N 1752
TC-N 1752
CAS#1211866-85-1

Theoretical Analysis

MedKoo Cat#: 574898

Name: TC-N 1752

CAS#: 1211866-85-1

Chemical Formula: C25H27F3N6O3

Exact Mass: 516.2097

Molecular Weight: 516.52

Elemental Analysis: C, 58.13; H, 5.27; F, 11.03; N, 16.27; O, 9.29

Price and Availability

Size Price Availability Quantity
10mg USD 335.00 2 Weeks
50mg USD 975.00 2 Weeks
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Related CAS #
No Data
Synonym
TC-N 1752
IUPAC/Chemical Name
N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide
InChi Key
QLKAFHZJICDACE-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H27F3N6O3/c1-16-21(31-17(2)35)4-3-5-22(16)32-23-29-15-30-24(33-23)34-12-10-19(11-13-34)36-14-18-6-8-20(9-7-18)37-25(26,27)28/h3-9,15,19H,10-14H2,1-2H3,(H,31,35)(H,29,30,32,33)
SMILES Code
CC(NC1=CC=CC(NC2=NC(N3CCC(OCC4=CC=C(OC(F)(F)F)C=C4)CC3)=NC=N2)=C1C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 516.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Bregman et al (2011) Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J.Med.Chem. 54 4427 PMID: 21634377 2. Lin et al (2016) Biophysical and pharmacological characterization of Nav1.9 voltage dependent sodium channels stably expressed in HEK-293 cells. PLoS One. 11 PMID: 27556810