MedKoo Cat#: 574886 | Name: Tadalafil hydroxypiperidone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tadalafil hydroxypiperidone is an impurity of Tadalafil -- a phosphodiesterase 5-inhibitor used for the treatment of erectile dysfunction.

Chemical Structure

Tadalafil hydroxypiperidone
Tadalafil hydroxypiperidone
CAS#1978322-99-4

Theoretical Analysis

MedKoo Cat#: 574886

Name: Tadalafil hydroxypiperidone

CAS#: 1978322-99-4

Chemical Formula: C22H19N3O6

Exact Mass: 421.1274

Molecular Weight: 421.41

Elemental Analysis: C, 62.70; H, 4.54; N, 9.97; O, 22.78

Price and Availability

Size Price Availability Quantity
1mg USD 295.00 2 Weeks
5mg USD 815.00 2 Weeks
10mg USD 1,385.00 2 Weeks
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Related CAS #
No Data
Synonym
Tadalafil hydroxypiperidone; Tadalafil EP Impurity E
IUPAC/Chemical Name
(6R,12bR)-6-(benzo[d][1,3]dioxol-5-yl)-6a-hydroxy-2-methyl-2,3,6a,7,12a,12b-hexahydropyrazino[1',2':1,5]pyrrolo[3,4-b]quinoline-1,4,12(6H)-trione
InChi Key
LKWAXSOKGBBZRU-UZGQDQSDSA-N
InChi Code
InChI=1S/C22H19N3O6/c1-24-9-16(26)25-18(21(24)28)17-19(27)12-4-2-3-5-13(12)23-22(17,29)20(25)11-6-7-14-15(8-11)31-10-30-14/h2-8,17-18,20,23,29H,9-10H2,1H3/t17?,18-,20-,22?/m1/s1
SMILES Code
OC1(NC2=CC=CC=C32)[C@@H](C4=CC=C5C(OCO5)=C4)N(C(CN6C)=O)[C@](C6=O)([H])C1C3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. Int Urol Nephrol. 2017 Oct;49(10):1731-1740. doi: 10.1007/s11255-017-1644-5. Epub 2017 Jul 24. PMID: 28741090; PMCID: PMC5603624.