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MedKoo Cat#: 463103 | Name: HSGN-218

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HSGN-218 is an Ultrapotent Inhibitor of Clostridioides difficile Growth, Which Suppresses Recurrence In Vivo. HSGN-218, is nontoxic to mammalian colon cells and is gutrestrictive. In addition, HSGN-218 protected mice from CDI recurrence.

Chemical Structure

HSGN-218
HSGN-218
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463103

Name: HSGN-218

CAS#: unknown

Chemical Formula: C16H8Cl2F3N3O2S

Exact Mass: 432.9666

Molecular Weight: 434.21

Elemental Analysis: C, 44.26; H, 1.86; Cl, 16.33; F, 13.13; N, 9.68; O, 7.37; S, 7.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
HSGN-218; HSGN218; HSGN 218;
IUPAC/Chemical Name
N-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-4-((trifluoromethyl)thio)benzamide
InChi Key
YNSLXRYEPGHGRY-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H8Cl2F3N3O2S/c17-10-5-9(6-11(18)7-10)14-23-24-15(26-14)22-13(25)8-1-3-12(4-2-8)27-16(19,20)21/h1-7H,(H,22,24,25)
SMILES Code
O=C(NC1=NN=C(C2=CC(Cl)=CC(Cl)=C2)O1)C3=CC=C(SC(F)(F)F)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Naclerio GA, Abutaleb NS, Li D, Seleem MN, Sintim HO. Ultrapotent Inhibitor of Clostridioides difficile Growth, Which Suppresses Recurrence In Vivo. J Med Chem. 2020 Oct 6. doi: 10.1021/acs.jmedchem.0c01198. Epub ahead of print. PMID: 32960605.

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