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MedKoo Cat#: 463099 | Name: E 0702

Description:

WARNING: This product is for research use only, not for human or veterinary use.

E-0702 is an antipseudomonal cephalosporin derivative which has a broad spectrum of antibacterial activity against clinical isolates of gram-positive and gram-negative bacteria. It has significantly high in vitro antibacterial activity against gram-negative bacteria including the Pseudomonas group.

Chemical Structure

E 0702
E 0702
CAS#77768-57-1

Theoretical Analysis

MedKoo Cat#: 463099

Name: E 0702

CAS#: 77768-57-1

Chemical Formula: C29H21N7Na2O12S2

Exact Mass: 769.0485

Molecular Weight: 769.62

Elemental Analysis: C, 45.26; H, 2.75; N, 12.74; Na, 5.97; O, 24.95; S, 8.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
E 0702; E0702; E-0702;
IUPAC/Chemical Name
sodium (6R,7R)-3-(((1-(carboxylatomethyl)-1H-tetrazol-5-yl)thio)methyl)-7-(2-(6,7-dihydroxy-4-oxo-4H-chromene-3-carboxamido)-2-(4-hydroxyphenyl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
HJWFZVYGOATFNO-RPGKBGGYSA-L
InChi Code
InChI=1S/C29H23N7O12S2.2Na/c37-13-3-1-11(2-4-13)20(30-24(43)15-8-48-18-6-17(39)16(38)5-14(18)23(15)42)25(44)31-21-26(45)36-22(28(46)47)12(9-49-27(21)36)10-50-29-32-33-34-35(29)7-19(40)41;;/h1-6,8,20-21,27,37-39H,7,9-10H2,(H,30,43)(H,31,44)(H,40,41)(H,46,47);;/q;2*+1/p-2/t20?,21-,27-;;/m1../s1
SMILES Code
O=C(C(N12)=C(CSC3=NN=NN3CC([O-])=O)CS[C@]2([H])[C@H](NC(C(NC(C4=COC5=CC(O)=C(O)C=C5C4=O)=O)C6=CC=C(O)C=C6)=O)C1=O)[O-].[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 769.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Watanabe NA, Nagasu T, Katsu K, Kitoh K. E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system. Antimicrob Agents Chemother. 1987 Apr;31(4):497-504. doi: 10.1128/aac.31.4.497. PMID: 3037997; PMCID: PMC174766. 2: Neu HC, Labthavikul P. In vitro antibacterial activity and beta-lactamase stability of E-0702, a new cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):313-20. doi: 10.1128/aac.24.3.313. PMID: 6605718; PMCID: PMC185318. 3: Katsu K, Kitoh K, Inoue M, Mitsuhashi S. In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin. Antimicrob Agents Chemother. 1982 Aug;22(2):181-5. doi: 10.1128/aac.22.2.181. PMID: 6100421; PMCID: PMC183706.