Synonym
CP102; CP 102; CP-102;
IUPAC/Chemical Name
2-ethyl-3-hydroxy-1-(2-hydroxyethyl)pyridin-4(1H)-one
InChi Key
QEUNHAYEJPIRIA-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H13NO3/c1-2-7-9(13)8(12)3-4-10(7)5-6-11/h3-4,11,13H,2,5-6H2,1H3
SMILES Code
O=C1C(O)=C(CC)N(CCO)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
1.0 |
5.46 |
| DMSO |
1.0 |
5.46 |
| PBS (pH 7.2) |
1.0 |
5.46 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
183.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu DY, Liu ZD, Lu SL, Hider RC. Liquid extraction and ion-pair HPLC for determination of hydrophilic 3-hydroxypyridin-4-one iron chelators. J Pharm Biomed Anal. 1999 Dec;21(4):759-65. doi: 10.1016/s0731-7085(99)00211-3. PMID: 10701941.
2: Liu ZD, Liu DY, Lu SL, Hider RC. Synthesis, physicochemical properties and biological evaluation of aromatic ester prodrugs of 1-(2'-hydroxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP102): orally active iron chelators with clinical potential. J Pharm Pharmacol. 1999 May;51(5):555-64. doi: 10.1211/0022357991772655. PMID: 10411215.
3: Zanninelli G, Choudury R, Loréal O, Guyader D, Lescoat G, Arnaud J, Verna R, Cosson B, Singh S, Hider RC, Brissot P. Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non- transferrin-bound iron in rats. J Hepatol. 1997 Jul;27(1):176-84. doi: 10.1016/s0168-8278(97)80299-1. PMID: 9252093.
4: Choudhury R, Epemolu RO, Rai BL, Hider RC, Singh S. Metabolism and pharmacokinetics of 1-(2'-trimethylacetoxyethyl)-2-ethyl-3-hydroxypyridin-4-one (CP117) in the rat. Drug Metab Dispos. 1997 Mar;25(3):332-9. PMID: 9172951.
5: Smith AG, Clothier B, Francis JE, Gibbs AH, De Matteis F, Hider RC. Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn mice. Blood. 1997 Feb 1;89(3):1045-51. PMID: 9028337.
6: Singh S, Choudhury R, Epemolu RO, Hider RC. Metabolism and pharmacokinetics of 1-(2'-hydroxy-ethyl)- and 1-(3'-hydroxypropyl)-2-ethyl-3-hydroxypyridin-4-ones in the rat. Eur J Drug Metab Pharmacokinet. 1996 Jan-Mar;21(1):33-41. doi: 10.1007/BF03190276. PMID: 8839676.
7: Choudhury R, Singh S. Effect of iron overload on the metabolism and urinary recovery of 3-hydroxypyridin-4-one chelating agents in the rat. Drug Metab Dispos. 1995 Mar;23(3):314-20. PMID: 7628295.
