TSI-13-57 is a MyD88 inhibitor. TSI-13-57 likely binds directly the TIR-domain of MyD88 to prevent TLR-mediated cell activation. TSI-13-57 inhibited homodimerization of the TIR-domain of MyD88, but showed little inhibitory activity on the interaction between TLR9 and MyD88, and no activity against interaction between TIRAP and MyD88.
MedKoo Cat#: 463096
Name: TSI-13-57
CAS#: 2257427-45-3
Chemical Formula: C28H29N3O3
Exact Mass: 455.2209
Molecular Weight: 455.56
Elemental Analysis: C, 73.82; H, 6.42; N, 9.22; O, 10.54
The following data is based on the product molecular weight 455.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
