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MedKoo Cat#: 574866 | Name: RU-SKI 43

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU-SKI 43 is an inhibitor of Hedgehog acyltransferase (Hhat). It blocks Sonic hedgehog (Shh) signaling.

Chemical Structure

RU-SKI 43
RU-SKI 43
CAS#1043797-53-0

Theoretical Analysis

MedKoo Cat#: 574866

Name: RU-SKI 43

CAS#: 1043797-53-0

Chemical Formula: C22H30N2O2S

Exact Mass: 386.2028

Molecular Weight: 386.55

Elemental Analysis: C, 68.36; H, 7.82; N, 7.25; O, 8.28; S, 8.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RU-SKI 43
IUPAC/Chemical Name
1-[6,7-Dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-ethanone
InChi Key
AEENEMOEBJOKGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30N2O2S/c1-4-16(2)13-23-14-22(25)24-10-8-21-19(9-11-27-21)20(24)15-26-18-7-5-6-17(3)12-18/h5-7,9,11-12,16,20,23H,4,8,10,13-15H2,1-3H3
SMILES Code
CCC(C)CNCC(N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Petrova E, Matevossian A, Resh MD. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2015 Jan 8;34(2):263-8. doi: 10.1038/onc.2013.575. Epub 2014 Jan 27. PMID: 24469057; PMCID: PMC4513646. 2. Matevossian A, Resh MD. Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells. Mol Cancer. 2015 Apr 1;14:72. doi: 10.1186/s12943-015-0345-x. PMID: 25889650; PMCID: PMC4711017.