Synonym
RSVA-405; RSVA-405; RSVA-405
IUPAC/Chemical Name
(E)-N'-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
InChi Key
GWQPCBPAOAFXSJ-XDHOZWIPSA-N
InChi Code
InChI=1S/C17H20N4O2/c1-3-21(4-2)15-6-5-14(16(22)11-15)12-19-20-17(23)13-7-9-18-10-8-13/h5-12,22H,3-4H2,1-2H3,(H,20,23)/b19-12+
SMILES Code
CCN(C1=CC(O)=C(/C([H])=N/NC(C2=CC=NC=C2)=O)C=C1)CC
Appearance
Light Yellow Solid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Vingtdeux V, Chandakkar P, Zhao H, Davies P, Marambaud P. Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis. Mol Med. 2011 Sep-Oct;17(9-10):1022-30. doi: 10.2119/molmed.2011.00163. Epub 2011 Jun 1. PMID: 21647536; PMCID: PMC3188863.
2. Capiralla H, Vingtdeux V, Venkatesh J, Dreses-Werringloer U, Zhao H, Davies P, Marambaud P. Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages. FEBS J. 2012 Oct;279(20):3791-9. doi: 10.1111/j.1742-4658.2012.08739.x. Epub 2012 Sep 4. PMID: 22909341; PMCID: PMC3560297.
3: Madhavi, Y. V., Gaikwad, N., Yerra, V. G., Kalvala, A. K., Nanduri, S., & Kumar, A. (2019). Targeting AMPK in diabetes and diabetic complications: energy homeostasis, autophagy and mitochondrial health. Current medicinal chemistry, 26(27), 5207-5229.
