MedKoo Cat#: 463073 | Name: SIRT6 activator 12q
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIRT6 activator 12q is a novel SIRT6 activator, significantly inhibiting the proliferation and migration of pancreatic ductal adenocarcinoma (PDAC) cells in vitro and markedly suppressing the tumor growth in a PDAC tumor xenograft model.

Chemical Structure

SIRT6 activator 12q
CAS#2601734-99-8

Theoretical Analysis

MedKoo Cat#: 463073

Name: SIRT6 activator 12q

CAS#: 2601734-99-8

Chemical Formula: C31H22N2O2

Exact Mass: 454.1681

Molecular Weight: 454.53

Elemental Analysis: C, 81.92; H, 4.88; N, 6.16; O, 7.04

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
1g USD 4,250.00 2 Weeks
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Synonym
SIRT6 activator 12q; SIRT 6 activator 12q; SIRT-6 activator 12q;
IUPAC/Chemical Name
N-benzhydryl-2-(benzofuran-2-yl)quinoline-4-carboxamide
InChi Key
JNULQPRWYHVXHT-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H22N2O2/c34-31(33-30(21-11-3-1-4-12-21)22-13-5-2-6-14-22)25-20-27(32-26-17-9-8-16-24(25)26)29-19-23-15-7-10-18-28(23)35-29/h1-20,30H,(H,33,34)
SMILES Code
O=C(C1=CC(C2=CC3=CC=CC=C3O2)=NC4=CC=CC=C14)NC(C5=CC=CC=C5)C6=CC=CC=C6
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 454.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen X, Sun W, Huang S, Zhang H, Lin G, Li H, Qiao J, Li L, Yang S. Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity. J Med Chem. 2020 Sep 24;63(18):10474-10495. doi: 10.1021/acs.jmedchem.0c01183. Epub 2020 Sep 9. PMID: 32787077.