MedKoo Cat#: 574852 | Name: bPiDDB
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

bPiDDB is an orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist that attenuates nicotine-evoked dopamine release from the ventral tegmental area and reduces nicotine self-administration in rats.

Chemical Structure

bPiDDB
bPiDDB
CAS#525596-66-1

Theoretical Analysis

MedKoo Cat#: 574852

Name: bPiDDB

CAS#: 525596-66-1

Chemical Formula: C24H38Br2N2

Exact Mass: 512.1402

Molecular Weight: 514.39

Elemental Analysis: C, 56.04; H, 7.45; Br, 31.07; N, 5.45

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 1,050.00 2 Weeks
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Related CAS #
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Synonym
bPiDDB
IUPAC/Chemical Name
1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide
InChi Key
NNPBJCAIRCFEFZ-UHFFFAOYSA-L
InChi Code
InChI=1S/C24H38N2.2BrH/c1-23-15-13-19-25(21-23)17-11-9-7-5-3-4-6-8-10-12-18-26-20-14-16-24(2)22-26;;/h13-16,19-22H,3-12,17-18H2,1-2H3;2*1H/q+2;;/p-2
SMILES Code
CC1=C[N+](CCCCCCCCCCCC[N+]2=CC=CC(C)=C2)=CC=C1.[Br-].[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 514.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Dwoskin et al (2008) N,N'alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked DA release and hyperactivity. J.Pharmacol.Exp.Ther. 326 563 PMID: 18460644 2. Rahman et al (2008) Region-specific effects of the N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular DA in vivo. Br.J.Pharmacol. 153 792 PMID: 18059317 3. Ayers et al (2002) Bis-azaaromatic quaternary ammonium analogues: ligands for α4β2* and β7* subtypes of neuronal nicotinic receptors Bioorg.Med.Chem.Letts. 12 3067