MedKoo Cat#: 463057 | Name: AH057

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AH057 is a novel JAK inhibitor, effectively blocking the JAK/STAT pathways by directly inhibiting JAK1/2 kinase activities, and leading to compromised cell proliferation and invasion, increasing apoptosis, arrested cell cycles, and impairing tumor progression in vitro and in vivo

Chemical Structure

AH057
AH057
CAS#118499-11-9

Theoretical Analysis

MedKoo Cat#: 463057

Name: AH057

CAS#: 118499-11-9

Chemical Formula: C17H22N2O

Exact Mass: 270.1732

Molecular Weight: 270.38

Elemental Analysis: C, 75.52; H, 8.20; N, 10.36; O, 5.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AH057; AH 057; AH-057;
IUPAC/Chemical Name
(E)-2-((6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylidene)amino)butan-1-ol
InChi Key
WUPPLXLZQARPFF-FBMGVBCBSA-N
InChi Code
InChI=1S/C17H22N2O/c1-3-12(10-20)18-16-6-4-5-13-14-9-11(2)7-8-15(14)19-17(13)16/h7-9,12,19-20H,3-6,10H2,1-2H3/b18-16+
SMILES Code
CCC(CO)/N=C(CCC1)/C2=C1C3=C(N2)C=CC(C)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 270.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: She S, Zhao Y, Kang B, Chen C, Chen X, Zhang X, Chen W, Dan S, Wang H, Wang YJ, Zhao J. Combined inhibition of JAK1/2 and DNMT1 by newly identified small- molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells. Cell Death Dis. 2020 Sep 7;11(9):724. doi: 10.1038/s41419-020-02934-8. PMID: 32895373; PMCID: PMC7476923.