MedKoo Cat#: 463056 | Name: Ethyl-3,4-dephostatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ethyl-3,4-dephostatin is a novel inhibitor of the interactions of CFTR-associated ligand and PSD-95/Dlg1/ZO-1 domain.

Chemical Structure

Ethyl-3,4-dephostatin
Ethyl-3,4-dephostatin
CAS#237756-11-5

Theoretical Analysis

MedKoo Cat#: 463056

Name: Ethyl-3,4-dephostatin

CAS#: 237756-11-5

Chemical Formula: C8H10N2O3

Exact Mass: 182.0691

Molecular Weight: 182.18

Elemental Analysis: C, 52.74; H, 5.53; N, 15.38; O, 26.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Ethyl-3,4-dephostatin; ED;
IUPAC/Chemical Name
N-(3,4-dihydroxyphenyl)-N-ethylnitrous amide
InChi Key
ZTXUSFPBLYQDDN-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H10N2O3/c1-2-10(9-13)6-3-4-7(11)8(12)5-6/h3-5,11-12H,2H2,1H3
SMILES Code
O=NN(C1=CC=C(O)C(O)=C1)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain. Biosci Rep. 2018 Jul 6;38(4):BSR20180231. doi: 10.1042/BSR20180231. Erratum in: Biosci Rep. 2018 Jun 5;: PMID: 29472314; PMCID: PMC6435542. 2: Ren JX, Cheng Z, Huang YX, Zhao JF, Guo P, Zou ZM, Xie Y. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017 May;89:376-385. doi: 10.1016/j.biopha.2017.02.064. Epub 2017 Feb 27. PMID: 28249240. 3: Seo H, Cho S. Inhibition of dual-specificity phosphatase 26 by ethyl-3,4-dephostatin: Ethyl-3,4-dephostatin as a multiphosphatase inhibitor. Pharmazie. 2016 Apr;71(4):196-200. PMID: 27209699. 4: Akassoglou K. Nerve growth factor-independent neuronal survival: a role for NO donors. Mol Pharmacol. 2005 Oct;68(4):952-5. doi: 10.1124/mol.105.017277. Epub 2005 Jul 26. PMID: 16046659. 5: Culmsee C, Gerling N, Landshamer S, Rickerts B, Duchstein HJ, Umezawa K, Klumpp S, Krieglstein J. Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mol Pharmacol. 2005 Oct;68(4):1006-17. doi: 10.1124/mol.105.013086. Epub 2005 Jul 18. PMID: 16027232. 6: Tomes CN, Roggero CM, De Blas G, Saling PM, Mayorga LS. Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis. Dev Biol. 2004 Jan 15;265(2):399-415. doi: 10.1016/j.ydbio.2003.09.032. PMID: 14732401.