PD-149163 | CAS# 169528-11-4 | Neurotensin NTR1 receptor agonist

MedKoo Cat#: 574843 | Name: PD-149163

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cognitive, anti-psychotic and anxiolytic effects.

Chemical Structure

PD-149163

CAS#169528-11-4

Theoretical Analysis

MedKoo Cat#: 574843

Name: PD-149163

CAS#: 169528-11-4

Chemical Formula: C42H71N9O6

Exact Mass: 797.5527

Molecular Weight: 798.09

Elemental Analysis: C, 63.21; H, 8.97; N, 15.80; O, 12.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

PD-149163; PD149163; PD 149163; PF-01472472

IUPAC/Chemical Name

N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester

InChi Key

LVROVYGTQUFAMB-IDESOYSGSA-N

InChi Code

InChI=1S/C42H71N9O6/c1-7-57-41(56)34(23-27(2)3)49-39(54)36(42(4,5)6)50-37(52)33(24-28-25-46-31-17-9-8-16-30(28)31)48-38(53)35-19-14-22-51(35)40(55)32(18-11-13-21-44)47-26-29(45)15-10-12-20-43/h8-9,16-17,25,27,29,32-36,46-47H,7,10-15,18-24,26,43-45H2,1-6H3,(H,48,53)(H,49,54)(H,50,52)/t29-,32-,33-,34-,35-,36+/m0/s1

SMILES Code

CC(C)C[C@@H](C(OCC)=O)NC([C@H](C(C)(C)C)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H]3N(C([C@H](CCCCN)NC[C@@H](N)CCCCN)=O)CCC3)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 798.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Grimond-Billa SK, Norman C, G W B, Cassaday HJ. Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect. J Psychopharmacol. 2008 May;22(3):290-9. doi: 10.1177/0269881106081528. PMID: 18308776. 2. Vadnie CA, Ayers-Ringler J, Oliveros A, Abulseoud OA, Choi S, Hitschfeld MJ, Choi DS. Antipsychotic-like effects of a neurotensin receptor type 1 agonist. Behav Brain Res. 2016 May 15;305:8-17. doi: 10.1016/j.bbr.2016.02.019. Epub 2016 Feb 22. PMID: 26909848; PMCID: PMC4808331. 3. Steele FF 3rd, Whitehouse SC, Aday JS, Prus AJ. Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats. Brain Res. 2017 Mar 1;1658:31-35. doi: 10.1016/j.brainres.2017.01.012. Epub 2017 Jan 12. PMID: 28089664.