Synonym
Gastrofenzin; Gastrophenzine; Gastrophensin;
IUPAC/Chemical Name
ethyl (4-(4-chlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-8-yl)carbamate hydrochloride
InChi Key
MYXXVPPYQMJHGO-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21ClN2O2.ClH/c1-3-24-19(23)21-18-6-4-5-15-16(11-22(2)12-17(15)18)13-7-9-14(20)10-8-13;/h4-10,16H,3,11-12H2,1-2H3,(H,21,23);1H
SMILES Code
CCOC(Nc1c2c(C(c3ccc(Cl)cc3)CN(C2)C)ccc1)=O.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
381.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Antov G, Zaĭkov Kh, Mikhaĭlova A, Khalkova Zh, Popov T, Tasheva M, Mitova S, Dinoeva S, Kapurgov V. Toksikologichna kharakteristika na "Gastrofenzin". III. Khronichna oralna toksichnost [The toxicological characteristics of Gastrofenzin. III. Its chronic oral toxicity]. Probl Khig. 1996;21:96-102. Bulgarian. PMID: 9190605.
2: Mikhaĭlova A, Antov G, Khalkova Zh, Zaĭkov Kh, Tasheva M, Dinoeva S. Toksikologichna kharakteristika na "Gastrofenzin". II. Podostra oralna toksichnost [The toxicological characteristics of Gastrofenzin. II. Its subacute oral toxicity]. Probl Khig. 1996;21:88-96. Bulgarian. PMID: 9190604.
3: Khalkova Zh, Zaĭkov Kh, Antov G, Mikhaĭlova A, Ivanova N. Toksikologichna kharakteristika na "Gastrofenzin". I. Ostra toksichnost (oralna, podkozhna, intravenozna) [The toxicological characteristics of Gastrofenzin. I. Its acute toxicity (oral, subcutaneous and intravenous)]. Probl Khig. 1996;21:81-8. Bulgarian. PMID: 9190603.
4: Ilieva P, Ivanova-Chemishanska L, Antov G. Toksikologichna kharakteristika na "Gastrofenzin". IV. Gonadotropno deĭstvie [The toxicological characteristics of Gastrofenzin. IV. Its gonadotropic action]. Probl Khig. 1996;21:102-6. Bulgarian. PMID: 9190585.
5: Mirkova E. Genotoksichnost i kantserogenen potentsial na gastrofenzin [The genotoxicity and carcinogenic potential of gastrofenzin]. Eksp Med Morfol. 1994;32(3-4):57-68. Bulgarian. PMID: 8857033.
6: Ivanova N, Mondeshka D, Ivanov C, Angelova I, Terziyska S, Paskov V. A new class of antiulcer drugs. I. Antiulcer effect of AN5, a 4-phenyl- tetrahydroisoquinoline derivative, on different experimental models of ulcer in rats. Methods Find Exp Clin Pharmacol. 1990 Jul-Aug;12(6):401-10. PMID: 2087139.