NCX-466 is a Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor (CINOD) that inhibits COX-1 and COX-2 while releasing NO with higher efficacy than Naproxen, its congener drug, in reducing levels of profibrotic cytokine transforming growth factor-β and oxidative stress in a mouse model of bleomycin-induced lung fibrosis.
MedKoo Cat#: 574809
Name: NCX-466
CAS#: 1262956-64-8
Chemical Formula: C20H24N2O9
Exact Mass: 436.1482
Molecular Weight: 436.42
Elemental Analysis: C, 55.04; H, 5.54; N, 6.42; O, 32.99
The following data is based on the product molecular weight 436.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
