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MedKoo Cat#: 462972 | Name: Antide acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antide acetate is a third generation gonadotropin-releasing hormone receptor antagonist. It inhibits GnRH-induced secretion of luteinizing hormone, follicle-stimulating hormone, and gonadotropin in isolated rat pituitary cells when used at concentrations ranging from 0.001 to 1,000 nM but does not induce histamine release in isolated rat mast cells. Antide acetate reduces serum LH and FSH levels in orchidectomized cynomolgus monkeys. It inhibits ovulation in rats when administered at a dose of 2 µg/animal. Antide acetate reduces the intensity and duration of catalepsy induced by haloperidol in rats.

Chemical Structure

Antide acetate
Antide acetate
CAS#625092-10-6

Theoretical Analysis

MedKoo Cat#: 462972

Name: Antide acetate

CAS#: 625092-10-6

Chemical Formula: C84H112ClN17O16

Exact Mass: 1649.8161

Molecular Weight: 1651.37

Elemental Analysis: C, 61.10; H, 6.84; Cl, 2.15; N, 14.42; O, 15.50

Price and Availability

Size Price Availability Quantity
1mg USD 285.00 2 Weeks
5mg USD 700.00 2 Weeks
10mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
Antide acetate;
IUPAC/Chemical Name
N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-amino-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotinamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)nicotinamide acetate
InChi Key
RHBDDEILKDGLGU-OHURHHEJSA-N
InChi Code
InChI=1S/C82H108ClN17O14.C2H4O2/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55;1-2(3)4/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111);1H3,(H,3,4)/t52-,62+,63-,64+,65+,66-,67-,68-,69+,70+;/m1./s1
SMILES Code
ClC1=CC=C(C[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@@H](C(N)=O)C)=O)CCC2)=O)CCCCNC(C)C)=O)CC(C)C)=O)CCCCNC(C3=CN=CC=C3)=O)=O)CCCCNC(C4=CN=CC=C4)=O)=O)CO)=O)CC5=CN=CC=C5)=O)NC([C@@H](CC6=CC7=C(C=C6)C=CC=C7)NC(C)=O)=O)C=C1.O=C(O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,651.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hodgson AR, Richmond C, Tello J, Brown GR. Suppression of ovarian hormones in adolescent rats has no effect on anxiety-like behaviour or c-fos activation in the amygdala. J Neuroendocrinol. 2020 Sep;32(9):e12897. doi: 10.1111/jne.12897. Epub 2020 Sep 15. PMID: 32935383. 2: Faraoni V, Vachon G. When Painlevé-Gullstrand coordinates fail. Eur Phys J C Part Fields. 2020;80(8):771. doi: 10.1140/epjc/s10052-020-8345-4. Epub 2020 Aug 25. PMID: 32922164; PMCID: PMC7467130. 3: Magee C, Bruemmer JE, Kirkley KS, Sylvester LA, Runyan B, Nett TM, Squires EL, Clay CM. Kisspeptin has an independent and direct effect on the pituitary gland in the mare. Theriogenology. 2020 Jul 29;157:199-209. doi: 10.1016/j.theriogenology.2020.07.031. Epub ahead of print. PMID: 32814247. 4: García-Juárez M, Montes-Narváez O, Lima-Hernández FJ, Domínguez-Ordoñez R, Pfaus JG, González-Flores O. Tibolone facilitates lordosis behavior through estrogen, progestin, and GnRH-1 receptors in estrogen-primed rats. Neurosci Lett. 2020 Sep 25;736:135299. doi: 10.1016/j.neulet.2020.135299. Epub 2020 Aug 7. PMID: 32777349. 5: Holzegel G, Luk J, Smulevici J, Warnick C. Asymptotic Properties of Linear Field Equations in Anti-de Sitter Space. Commun Math Phys. 2020;374(2):1125-1178. doi: 10.1007/s00220-019-03601-6. Epub 2019 Nov 4. PMID: 32675827; PMCID: PMC7336248. 6: Plugge S, Lantagne-Hurtubise É, Franz M. Revival Dynamics in a Traversable Wormhole. Phys Rev Lett. 2020 Jun 5;124(22):221601. doi: 10.1103/PhysRevLett.124.221601. PMID: 32567928. 7: Bantilan H, Figueras P, Mateos D. Real-Time Dynamics of Plasma Balls from Holography. Phys Rev Lett. 2020 May 15;124(19):191601. doi: 10.1103/PhysRevLett.124.191601. PMID: 32469546. 8: Petrucci L, Maranesi M, Verini Supplizi A, Dall'Aglio C, Mandara MT, Quassinti L, Bramucci M, Miano A, Gobbetti A, Catone G, Boiti C, Zerani M. Kisspeptin/GnRH1 system in Leydig cells of horse (Equus caballus): Presence and function. Theriogenology. 2020 Aug;152:1-7. doi: 10.1016/j.theriogenology.2020.04.006. Epub 2020 Apr 15. PMID: 32339963. 9: Bhattacharyya A, Nandy P, Sinha A. Renormalized Circuit Complexity. Phys Rev Lett. 2020 Mar 13;124(10):101602. doi: 10.1103/PhysRevLett.124.101602. PMID: 32216439. 10: Malek E, Samtleben H. Kaluza-Klein Spectrometry for Supergravity. Phys Rev Lett. 2020 Mar 13;124(10):101601. doi: 10.1103/PhysRevLett.124.101601. PMID: 32216423. 11: Kusuki Y, Miyaji M. Entanglement Entropy after Double Excitation as an Interaction Measure. Phys Rev Lett. 2020 Feb 14;124(6):061601. doi: 10.1103/PhysRevLett.124.061601. PMID: 32109125. 12: Kotarba G, Zielinska-Gorska M, Biernacka K, Gajewska A. Gonadotropin- releasing hormone-Cu complex (Cu-GnRH) transcriptional activity in vivo in the female rat anterior pituitary gland. Brain Res Bull. 2020 Mar;156:67-75. doi: 10.1016/j.brainresbull.2020.01.005. Epub 2020 Jan 10. PMID: 31931118. 13: Suzuki Y, Takayanagi T, Umemoto K. Entanglement Wedges from the Information Metric in Conformal Field Theories. Phys Rev Lett. 2019 Nov 29;123(22):221601. doi: 10.1103/PhysRevLett.123.221601. PMID: 31868416. 14: Maraner P, Pachos JK, Palumbo G. Specific heat of 2D interacting Majorana fermions from holography. Sci Rep. 2019 Nov 21;9(1):17308. doi: 10.1038/s41598-019-53771-5. PMID: 31754192; PMCID: PMC6872579. 15: Bohm-Levine N, Goldberg AR, Mariani M, Frankfurt M, Thornton J. Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Horm Behav. 2020 Feb;118:104590. doi: 10.1016/j.yhbeh.2019.104590. Epub 2019 Nov 9. PMID: 31593698. 16: Brandão FGSL, Crosson E, Şahinoğlu MB, Bowen J. Quantum Error Correcting Codes in Eigenstates of Translation-Invariant Spin Chains. Phys Rev Lett. 2019 Sep 13;123(11):110502. doi: 10.1103/PhysRevLett.123.110502. PMID: 31573226. 17: Bernamonti A, Galli F, Hernandez J, Myers RC, Ruan SM, Simón J. First Law of Holographic Complexity. Phys Rev Lett. 2019 Aug 23;123(8):081601. doi: 10.1103/PhysRevLett.123.081601. PMID: 31491207. 18: Wei SW, Liu YX, Mann RB. Repulsive Interactions and Universal Properties of Charged Anti-de Sitter Black Hole Microstructures. Phys Rev Lett. 2019 Aug 16;123(7):071103. doi: 10.1103/PhysRevLett.123.071103. PMID: 31491095. 19: Bobenko AI, Heller S, Schmitt N. Minimal n-noids in hyperbolic and anti-de Sitter 3-space. Proc Math Phys Eng Sci. 2019 Jul;475(2227):20190173. doi: 10.1098/rspa.2019.0173. Epub 2019 Jul 17. PMID: 31423097; PMCID: PMC6694303. 20: Ozkan M, Pang Y, Zorba U. Unitary Extension of Exotic Massive 3D Gravity from Bigravity. Phys Rev Lett. 2019 Jul 19;123(3):031303. doi: 10.1103/PhysRevLett.123.031303. PMID: 31386429.

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