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MedKoo Cat#: 462953 | Name: Cimbuterol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cimbuterol is an agonist of β-adrenergic receptors. It has been used as a standard for the simultaneous detection of multiple veterinary residues in commercial animal meat by LC-MS/MS. Formulations containing cimbuterol have been used to promote growth and improve feed efficiency in livestock.

Chemical Structure

Cimbuterol
Cimbuterol
CAS#54239-39-3

Theoretical Analysis

MedKoo Cat#: 462953

Name: Cimbuterol

CAS#: 54239-39-3

Chemical Formula: C13H19N3O

Exact Mass: 233.1528

Molecular Weight: 233.32

Elemental Analysis: C, 66.92; H, 8.21; N, 18.01; O, 6.86

Price and Availability

Size Price Availability Quantity
5mg USD 325.00 2 Weeks
10mg USD 585.00 2 Weeks
25mg USD 1,050.00 2 Weeks
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Related CAS #
No Data
Synonym
Cimbuterol;
IUPAC/Chemical Name
2-amino-5-(2-(tert-butylamino)-1-hydroxyethyl)benzonitrile
InChi Key
YKKQAXQGZIBJFS-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19N3O/c1-13(2,3)16-8-12(17)9-4-5-11(15)10(6-9)7-14/h4-6,12,16-17H,8,15H2,1-3H3
SMILES Code
N#CC1=CC(C(O)CNC(C)(C)C)=CC=C1N
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 233.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tu Y, Zhong J, Wang H, Pan J, Xu Z, Yang W, Luo Y. Synthesis of stable isotope labeled D9 -Mabuterol, D9 -Bambuterol, and D9 -Cimbuterol. J Labelled Comp Radiopharm. 2016 Nov;59(13):546-551. doi: 10.1002/jlcr.3446. Epub 2016 Oct 13. PMID: 27739098. 2: Xu X, Xu X, Sun L, Wu A, Song S, Kuang H, Xu C. An ultrasensitive colloidal gold immunosensor to simultaneously detect 12 beta (2)-adrenergic agonists. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Feb 15;1191:123119. doi: 10.1016/j.jchromb.2022.123119. Epub 2022 Jan 20. PMID: 35091293. 3: Mastrianni KR, Metavarayuth K, Brewer WE, Wang Q. Analysis of 10 β-agonists in pork meat using automated dispersive pipette extraction and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 1;1084:64-68. doi: 10.1016/j.jchromb.2018.03.026. Epub 2018 Mar 14. PMID: 29571118. 4: Wu K, Guo L, Xu W, Xu H, Aguilar ZP, Xu G, Lai W, Xiong Y, Wan Y. Sulfonated polystyrene magnetic nanobeads coupled with immunochromatographic strip for clenbuterol determination in pork muscle. Talanta. 2014 Nov;129:431-7. doi: 10.1016/j.talanta.2014.06.007. Epub 2014 Jun 14. PMID: 25127616. 5: Wang R, Zhang W, Wang P, Su X. A paper-based competitive lateral flow immunoassay for multi β-agonist residues by using a single monoclonal antibody labelled with red fluorescent nanoparticles. Mikrochim Acta. 2018;185(3):191. doi: 10.1007/s00604-018-2730-9. Epub 2018 Feb 22. PMID: 29503465; PMCID: PMC5823949. 6: Di Corcia D, Morra V, Pazzi M, Vincenti M. Simultaneous determination of beta2-agonists in human urine by fast-gas chromatography/mass spectrometry: method validation and clinical application. Biomed Chromatogr. 2010 Apr;24(4):358-66. doi: 10.1002/bmc.1300. PMID: 19642085. 7: Nie J, Zhu M, Lian J, Pan Y, Deng X, Hu C. [Determination of fifteen beta- agonists in animal urine by high performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2010 Aug;28(8):759-64. Chinese. doi: 10.3724/sp.j.1123.2010.00759. PMID: 21261043. 8: Wang Z, Yue H, Wang Y, Wang L, Fu Z. A highly sensitive CE-chemiluminescence method for the determination of sympathomimetic drugs in urine samples by a facile precolumn derivatization using acridinium ester. Electrophoresis. 2014 Apr;35(7):1000-3. doi: 10.1002/elps.201300314. PMID: 24812684. 9: Xu W, Chen X, Huang X, Yang W, Liu C, Lai W, Xu H, Xiong Y. Ru(phen)3(2+) doped silica nanoparticle based immunochromatographic strip for rapid quantitative detection of β-agonist residues in swine urine. Talanta. 2013 Sep 30;114:160-6. doi: 10.1016/j.talanta.2013.04.013. Epub 2013 Apr 12. PMID: 23953456. 10: Us MF, Alshana U, Lubbad I, Göğer NG, Ertaş N. Dispersive liquid-liquid microextraction based on solidification of floating organic drop combined with field-amplified sample injection in capillary electrophoresis for the determination of beta(2)-agonists in bovine urine. Electrophoresis. 2013 Mar;34(6):854-61. doi: 10.1002/elps.201200348. PMID: 23335131. 11: Granja RH, Montes Niño AM, Rabone F, Montes Niño RE, Cannavan A, Salerno AG. Validation of radioimmunoassay screening methods for beta-agonists in bovine liver according to Commission Decision 2002/657/EC. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Dec;25(12):1475-81. doi: 10.1080/02652030802308464. PMID: 19680857. 12: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi: 10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PMID: 26304337. 13: Haasnoot W, Stouten P, Schilt R, Hooijerink D. A fast immunoassay for the screening of beta-agonists in hair. Analyst. 1998 Dec;123(12):2707-10. doi: 10.1039/a805041d. PMID: 10435328. 14: Spisso BF, Lopes CC, Marques MA, Neto FR. Determination of beta2-agonists in bovine urine: comparison of two extraction/clean-up procedures for high- resolution gas chromatography-mass spectrometry analysis. J Anal Toxicol. 2000 Mar;24(2):146-52. doi: 10.1093/jat/24.2.146. PMID: 10732954. 15: Visser T, Vredenbregt MJ, de Jong AP, van Rossum HJ, Stephany RW, van Ginkel LA. Confirmational analysis of beta-agonists by cryotrapping gas chromatography- Fourier transform infrared spectrometry. Analyst. 1994 Dec;119(12):2681-5. doi: 10.1039/an9941902681. PMID: 7879875.