ML-243 | CAS# 1426576-80-8 | Cancer stem cell inhibitor

MedKoo Cat#: 574790 | Name: ML-243

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML-243 is an inhibitor of cancer stem cells and weakly antagonizes the adenosine A2A receptor.

Chemical Structure

ML-243

CAS#1426576-80-8

Theoretical Analysis

MedKoo Cat#: 574790

Name: ML-243

CAS#: 1426576-80-8

Chemical Formula: C14H16N2OS

Exact Mass: 260.0983

Molecular Weight: 260.36

Elemental Analysis: C, 64.59; H, 6.19; N, 10.76; O, 6.15; S, 12.31

Price and Availability

Size	Price	Availability
5mg	USD 235.00	2 Weeks
10mg	USD 385.00	2 Weeks
25mg	USD 650.00	2 Weeks
50mg	USD 945.00	2 Weeks
100mg	USD 1,385.00	2 Weeks

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Related CAS #

No Data

Synonym

CID-50910523; ML-243; ML243; ML 243

IUPAC/Chemical Name

(2E)-N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-2-propenamide

InChi Key

MTLJBAFNMHPGBV-BQYQJAHWSA-N

InChi Code

InChI=1S/C14H16N2OS/c1-2-11-3-5-12(6-4-11)7-8-13(17)16-14-15-9-10-18-14/h3-8H,2,9-10H2,1H3,(H,15,16,17)/b8-7+

SMILES Code

O=C(NC1=NCCS1)/C=C/C2=CC=C(CC)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

ML243 is a selective small-molecule inhibitor of breast cancer stem cells.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	5.0	19.20

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 260.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Carmody, L., Germain, A., Morgan, B., et al. Identification of a selective small-molecule inhibitor of breast cancer stem cells - Probe 3. 3, 1-13 (2011).