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MedKoo Cat#: 574784 | Name: Miltirone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Miltirone is a potential biomarker for the consumption of common sage, herbs and spices, and rosemary.

Chemical Structure

Miltirone
Miltirone
CAS#27210-57-7

Theoretical Analysis

MedKoo Cat#: 574784

Name: Miltirone

CAS#: 27210-57-7

Chemical Formula: C19H22O2

Exact Mass: 282.1620

Molecular Weight: 282.38

Elemental Analysis: C, 80.82; H, 7.85; O, 11.33

Price and Availability

Size Price Availability Quantity
5mg USD 515.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
Miltirone
IUPAC/Chemical Name
8,8-dimethyl-2-propan-2-yl-6,7-dihydro-5H-phenanthrene-3,4-dione
InChi Key
FEFAIBOZOKSLJR-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22O2/c1-11(2)14-10-12-7-8-15-13(6-5-9-19(15,3)4)16(12)18(21)17(14)20/h7-8,10-11H,5-6,9H2,1-4H3
SMILES Code
O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CCC3)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM.
In vitro activity:
Effect of miltirone on the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway was explored by western blot analysis. Miltirone or N-acetylcysteine (NAC) attenuated MPP+-induced reduction in cell viability, ROS production, SOD activity reduction, apoptosis, and increase of caspase-3 activity. Additionally, miltirone recuperated MPP+-induced inactivation of the PI3K/Akt pathway. Reference: Neurochem Res. 2022 Oct;47(10):3137-3149. https://pubmed.ncbi.nlm.nih.gov/35810264/
In vivo activity:
Miltirone significantly inhibited tumor growth and induced pyroptosis in the Hepa1-6 mouse HCC syngeneic model. These results provide a new insight that miltirone is a potential therapeutic agent for the treatment of HCC via GSDME-dependent pyroptosis. Reference: Acta Pharm Sin B. 2020 Aug;10(8):1397-1413. https://pubmed.ncbi.nlm.nih.gov/32963939/
Solvent mg/mL mM comments
Solubility
DMSO 50.0 177.06
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 282.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Zheng Z, Guo M, Zhu W, Cheng W, Kong L, Liu Y, Qiu Y, Wang X, Wang Y, Cui H. Identification of JUN as determinant of osteoarthritis and its inhibition by the Chinese herbal formulae Zhuanggu Huoxue Tang. Comput Biol Med. 2022 Sep;148:105786. doi: 10.1016/j.compbiomed.2022.105786. Epub 2022 Jun 30. PMID: 35926267. 2. Feng H, Xi F. Miltirone Attenuates Reactive Oxygen Species-Dependent Neuronal Apoptosis in MPP+-Induced Cell Model of Parkinson's Disease Through Regulating the PI3K/Akt Pathway. Neurochem Res. 2022 Oct;47(10):3137-3149. doi: 10.1007/s11064-022-03669-y. Epub 2022 Jul 9. PMID: 35810264. 3. Zhang X, Zhang P, An L, Sun N, Peng L, Tang W, Ma D, Chen J. Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis. Acta Pharm Sin B. 2020 Aug;10(8):1397-1413. doi: 10.1016/j.apsb.2020.06.015. Epub 2020 Jul 2. PMID: 32963939; PMCID: PMC7488361. 4. Wang H, Gu J, Hou X, Chen J, Yang N, Liu Y, Wang G, Du M, Qiu H, Luo Y, Jiang Z, Feng L. Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-κB/IQGAP2 signaling pathway. Biomed Pharmacother. 2017 Jan;85:531-540. doi: 10.1016/j.biopha.2016.11.061. Epub 2016 Nov 27. PMID: 27903427.
In vitro protocol:
1. Zheng Z, Guo M, Zhu W, Cheng W, Kong L, Liu Y, Qiu Y, Wang X, Wang Y, Cui H. Identification of JUN as determinant of osteoarthritis and its inhibition by the Chinese herbal formulae Zhuanggu Huoxue Tang. Comput Biol Med. 2022 Sep;148:105786. doi: 10.1016/j.compbiomed.2022.105786. Epub 2022 Jun 30. PMID: 35926267. 2. Feng H, Xi F. Miltirone Attenuates Reactive Oxygen Species-Dependent Neuronal Apoptosis in MPP+-Induced Cell Model of Parkinson's Disease Through Regulating the PI3K/Akt Pathway. Neurochem Res. 2022 Oct;47(10):3137-3149. doi: 10.1007/s11064-022-03669-y. Epub 2022 Jul 9. PMID: 35810264.
In vivo protocol:
1. Zhang X, Zhang P, An L, Sun N, Peng L, Tang W, Ma D, Chen J. Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis. Acta Pharm Sin B. 2020 Aug;10(8):1397-1413. doi: 10.1016/j.apsb.2020.06.015. Epub 2020 Jul 2. PMID: 32963939; PMCID: PMC7488361. 2. Wang H, Gu J, Hou X, Chen J, Yang N, Liu Y, Wang G, Du M, Qiu H, Luo Y, Jiang Z, Feng L. Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-κB/IQGAP2 signaling pathway. Biomed Pharmacother. 2017 Jan;85:531-540. doi: 10.1016/j.biopha.2016.11.061. Epub 2016 Nov 27. PMID: 27903427.