MedKoo Cat#: 574764 | Name: KF-38789
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KF-38789 is a selective inhibitor of P-selectin-mediated cell adhesion that blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.

Chemical Structure

KF-38789
KF-38789
CAS#257292-29-8

Theoretical Analysis

MedKoo Cat#: 574764

Name: KF-38789

CAS#: 257292-29-8

Chemical Formula: C19H21NO5S

Exact Mass: 375.1140

Molecular Weight: 375.44

Elemental Analysis: C, 60.78; H, 5.64; N, 3.73; O, 21.31; S, 8.54

Price and Availability

Size Price Availability Quantity
10mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
KF-38789, KF38789, KF 38789
IUPAC/Chemical Name
3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
InChi Key
NHFIAAAMCYVRIW-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21NO5S/c1-11-8-15(21)18(19(22)25-11)14-10-17(26-7-6-20-14)13-5-4-12(23-2)9-16(13)24-3/h4-5,8-9,17,21H,6-7,10H2,1-3H3
SMILES Code
O=C1C(C2=NCCSC(C3=CC=C(OC)C=C3OC)C2)=C(O)C=C(C)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 375.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275 PMID: 10780927 2. Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544 PMID: 11766994 3. Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21 PMID: 17201408