Kanosamine | CAS# 57649-10-2 | Antibiotic

MedKoo Cat#: 574761 | Name: Kanosamine HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kanosamine is an antibiotic that inhibits cell wall synthesis in plant-pathogenic oomycetes, certain fungi, and some bacterial species. It has been explored as an alternative and/or supplement to synthetic pesticides and genetic resistance of crop plants for the management of plant disease.

Chemical Structure

Kanosamine HCl

CAS#57649-10-2

Theoretical Analysis

MedKoo Cat#: 574761

Name: Kanosamine HCl

CAS#: 57649-10-2

Chemical Formula: C6H14ClNO5

Exact Mass: 215.0561

Molecular Weight: 215.63

Elemental Analysis: C, 33.42; H, 6.54; Cl, 16.44; N, 6.50; O, 37.10

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 450.00	2 Weeks
10mg	USD 800.00	2 Weeks

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Synonym

Kanosamine HCl

IUPAC/Chemical Name

3-amino-3-deoxy-D-glucose, monohydrochloride

InChi Key

ADFOMBKCPIMCOO-BTVCFUMJSA-N

InChi Code

InChI=1S/C6H13NO5.ClH/c7-5(3(10)1-8)6(12)4(11)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6+;/m0./s1

SMILES Code

O=C([H])[C@H](O)[C@@H](N)[C@H](O)[C@H](O)CO.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few Bacterial species.

In vitro activity:

Kanosamine was highly inhibitory to growth of plant-pathogenic oomycetes and moderately inhibitory to certain fungi and inhibited few bacterial species tested. Reference: Appl Environ Microbiol. 1996 Aug;62(8):3061-5. https://pubmed.ncbi.nlm.nih.gov/8702302/

In vivo activity:

	Solvent	mg/mL	mM
Solubility
	DMF	25.0	115.94
	DMSO	25.0	115.94
	Ethanol	5.0	23.19
	PBS (pH 7.2)	10.0	46.38

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 215.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Milner JL, Silo-Suh L, Lee JC, He H, Clardy J, Handelsman J. Production of kanosamine by Bacillus cereus UW85. Appl Environ Microbiol. 1996 Aug;62(8):3061-5. doi: 10.1128/aem.62.8.3061-3065.1996. PMID: 8702302; PMCID: PMC168096.

In vitro protocol:

In vivo protocol:

1. Milner, J.L., Silo-Suh, L., Lee, J.C., et al. Production of kanosamine by Bacillus cereus UW85. Appl. Environ. Microbiol. 62(8), 3061-3065 (1996). 2. Dolak, L.A., Castle, T.M., Dietz, A., et al. 3-Amino-3-deoxyglucose produced by a Streptomyces sp. J.Antibiot.(Tokyo) 33(8), 900-901 (1980).