MedKoo Cat#: 462891 | Name: Ambocarb

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ambocarb is a novel nootropic beta-carboline. It was shown to have a learning-enhancing effect when tested on rats by potently and reversibly suppressing sodium currents in rat isolated hippocampal pyramidal neurons.

Chemical Structure

Ambocarb
Ambocarb
CAS#96725-29-0

Theoretical Analysis

MedKoo Cat#: 462891

Name: Ambocarb

CAS#: 96725-29-0

Chemical Formula: C18H18N2O

Exact Mass: 278.1419

Molecular Weight: 278.36

Elemental Analysis: C, 77.67; H, 6.52; N, 10.06; O, 5.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ambokarb;
IUPAC/Chemical Name
2,2,6-trimethyl-2,3,4,7-tetrahydro-1H-indolo[2,3-c]quinolin-1-one
InChi Key
LPEPDWACHDVAIC-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18N2O/c1-10-16-14(11-6-4-5-7-12(11)20-16)15-13(19-10)8-9-18(2,3)17(15)21/h4-7,20H,8-9H2,1-3H3
SMILES Code
O=C1C2=C3C(NC4=C3C=CC=C4)=C(C)N=C2CCC1(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 278.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kopanitsa MV, Krishtal OA, Komissarov IV. Inhibitory action of ambocarb on voltage-operated sodium channels in rat isolated hippocampal pyramidal neurons. Clin Exp Pharmacol Physiol. 2000 Jan-Feb;27(1-2):46-54. doi: 10.1046/j.1440-1681.2000.03194.x. PMID: 10696528. 2: Kut'ko II, Sitchenko NM. O klinicheskoĭ éffektivnosti otechestvennogo preparata "Ambokarb" [The clinical efficacy of the Ukrainian preparation Ambocarb]. Lik Sprava. 1995 Sep-Dec;(9-12):96-8. Russian. PMID: 8983808. 3: Abramets II, Andreev PV, Samoĭlovich IM. Nootropnye veshchestva usilivaiut vyzyvaemuiu N-metil-D-aspartatom kratkosrochnuiu potentsiatsiiu sinapticheskoĭ peredachi v srezakh gippokampa krys [Nootropic substances enhance the N-methyl- D-aspartate-induced short-term potentiation of synaptic transmission in rat hippocampal slices]. Eksp Klin Farmakol. 1995 Jan-Feb;58(1):15-7. Russian. PMID: 7787685. 4: Titievsky AV, Railoma O, Nieminen SA, Airaksinen MM. Influence of flumazenil on the learning-enhancing effect of ambocarb in rats. Pharmacol Biochem Behav. 1994 Mar;47(3):681-8. doi: 10.1016/0091-3057(94)90174-0. PMID: 8208789. 5: Abramets II, Andreev PV, Komissarov IV, Samoĭlovich IM, Titievskiĭ AV. Nootropy potentsiruiut otvety nervnykh kletok, vyzyvaemye aktivatsieĭ NMDA- glutamatnykh retseptorov [Nootropic drugs potentiate nerve cell responses evoked by NMDA-glutamate receptor activation]. Biull Eksp Biol Med. 1993 Jan;115(1):51-3. Russian. PMID: 7914439.