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MedKoo Cat#: 574751 | Name: Ipidacrine Hydrochloride Hydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ipidacrine Hydrochloride Hydrate is used for treatment of memory dysfunctions, learning disability and dementia.

Chemical Structure

Ipidacrine Hydrochloride Hydrate
Ipidacrine Hydrochloride Hydrate
CAS#118499-70-0

Theoretical Analysis

MedKoo Cat#: 574751

Name: Ipidacrine Hydrochloride Hydrate

CAS#: 118499-70-0

Chemical Formula: C12H19ClN2O

Exact Mass:

Molecular Weight: 242.75

Elemental Analysis: C, 59.38; H, 7.89; Cl, 14.60; N, 11.54; O, 6.59

Price and Availability

Size Price Availability Quantity
250mg USD 250.00 2 Weeks
1g USD 550.00 2 Weeks
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Synonym
Ipidacrine Hydrochloride Hydrate
IUPAC/Chemical Name
2,3,5,6,7,8-Hexahydro-1H-Cyclopenta[b]quinolin-9-amine Monohydrochloride Monohydrate
InChi Key
SBTIBNSPYUUNGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16N2.ClH.H2O/c13-12-8-4-1-2-6-10(8)14-11-7-3-5-9(11)12;;/h1-7H2,(H2,13,14);1H;1H2
SMILES Code
NC1=C(CCC2)C2=NC3=C1CCCC3.[H]Cl.[H]O[H]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Ipidacrine Hydrochloride Hydrate is used for treatment of memory dysfunctions, learning disability and dementia.
In vitro activity:
NIK-247 (9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]-quinoline hydrochloride hydrate), an acetylcholinesterase inhibitor, is structurally related to 4-aminopyridine (AP). Its effects on ionic currents were examined in the artificial node of the crayfish axon under voltage-clamp. When applied externally, NIK-247 reversibly suppressed both inward and outward currents. NIK-247 suppressed the K current dose-dependently, but with an IC50 at of 10(-3) M. Furthermore, NIK-247 (and THA) suppressed the K current uniformly for the whole time course, whereas AP the AP's suppressed mainly the fast activating and inactivating K current with a voltage- and frequency-dependent recovery. Reference: Jpn J Pharmacol. 1991 Dec;57(4):545-52. https://pubmed.ncbi.nlm.nih.gov/1724992/
In vivo activity:
This is the first study to show that administration of ipidacrine, the reversible cholinesterase inhibitor, improved erectile function in diabetic rats and these results may be beneficial in further studies using ipidacrine for treatment of DMED, particularly in non-responders to PDE5 inhibitors. Reference: Sex Med. 2022 Feb;10(1):100477. https://pubmed.ncbi.nlm.nih.gov/35007992/

Preparing Stock Solutions

The following data is based on the product molecular weight 242.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kojima J, Sugawara Y, Obara S. NIK-247 blocks voltage-dependent ionic currents in crayfish axon. Jpn J Pharmacol. 1991 Dec;57(4):545-52. doi: 10.1254/jjp.57.545. PMID: 1724992. 2. Bykov V, Gushchina E, Morozov S, Zhuravskaya N, Kryshen K, Makarov V, Matichin A, Zueva A. Ipidacrine (Axamon), A Reversible Cholinesterase Inhibitor, Improves Erectile Function in Male Rats With Diabetes Mellitus-Induced Erectile Dysfunction. Sex Med. 2022 Feb;10(1):100477. doi: 10.1016/j.esxm.2021.100477. Epub 2022 Jan 8. PMID: 35007992; PMCID: PMC8847829. 3. Uemura K, Yoshioka S, Surina-Baumgartner DM, Tamagawa T, Miura H, Ueda M, Tamaya N, Iguchi A, Hotta N. Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats. Jpn J Pharmacol. 1999 Jan;79(1):113-5. doi: 10.1254/jjp.79.113. PMID: 10082325.
In vitro protocol:
1. Kojima J, Sugawara Y, Obara S. NIK-247 blocks voltage-dependent ionic currents in crayfish axon. Jpn J Pharmacol. 1991 Dec;57(4):545-52. doi: 10.1254/jjp.57.545. PMID: 1724992.
In vivo protocol:
1. Bykov V, Gushchina E, Morozov S, Zhuravskaya N, Kryshen K, Makarov V, Matichin A, Zueva A. Ipidacrine (Axamon), A Reversible Cholinesterase Inhibitor, Improves Erectile Function in Male Rats With Diabetes Mellitus-Induced Erectile Dysfunction. Sex Med. 2022 Feb;10(1):100477. doi: 10.1016/j.esxm.2021.100477. Epub 2022 Jan 8. PMID: 35007992; PMCID: PMC8847829. 2. Uemura K, Yoshioka S, Surina-Baumgartner DM, Tamagawa T, Miura H, Ueda M, Tamaya N, Iguchi A, Hotta N. Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats. Jpn J Pharmacol. 1999 Jan;79(1):113-5. doi: 10.1254/jjp.79.113. PMID: 10082325.
1. Onodera K, Kojima J, Wachi M. Ipidacrine (NIK-247), a novel antidementia, rapidly enters the brain and improves scopolamine-induced amnesia in rats during the Morris water maze task. Nihon Shinkei Seishin Yakurigaku Zasshi. 1998;18(2):33-37.