MedKoo Cat#: 462886 | Name: Lauryldimethylbetaine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lauryl Betaine is an amphoteric surfactant derived from N-dodecyl-N,N-dialkanol amine with protein denaturing potency.

Chemical Structure

Lauryldimethylbetaine
Lauryldimethylbetaine
CAS#683-10-3

Theoretical Analysis

MedKoo Cat#: 462886

Name: Lauryldimethylbetaine

CAS#: 683-10-3

Chemical Formula: C16H33NO2

Exact Mass: 271.2511

Molecular Weight: 271.45

Elemental Analysis: C, 70.80; H, 12.25; N, 5.16; O, 11.79

Price and Availability

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1g USD 485.00 2 Weeks
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Related CAS #
No Data
Synonym
Lauryldimethylammonioacetate; Dimethyllaurylbetaine; Lauryldimethylaminoacetic betaine; Laurylbetain;
IUPAC/Chemical Name
2-(dodecyldimethylammonio)acetate
InChi Key
DVEKCXOJTLDBFE-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H33NO2/c1-4-5-6-7-8-9-10-11-12-13-14-17(2,3)15-16(18)19/h4-15H2,1-3H3
SMILES Code
CCCCCCCCCCCC[N+](C)(CC([O-])=O)C
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Lauryl Betaine is an amphoteric surfactant derived from N-dodecyl-N,N-dialkanol amine with protein denaturing potency.
In vitro activity:
This study found that, among the six betaine derivatives, lauryl betaine showed the most potent antifungal activity. Furthermore, transcriptome changes in both C. neoformans and M. restricta cells grown in the presence of lauryl betaine were analyzed and the results indicated that the compound mainly affected cell membrane synthesis, particularly ergosterol synthesis. Overall, these data demonstrated that lauryl betaine influences ergosterol synthesis in C. neoformans and that the compound exerts a similar mechanism of action on M. restricta. Reference: Mycobiology. 2019 Jun 22;47(2):242-249. https://pubmed.ncbi.nlm.nih.gov/31448144/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 271.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Nemati M, Farajzadeh MA, Afshar Mogaddam MR. Development of a surfactant-assisted dispersive solid phase extraction using deep eutectic solvent to extract four tetracycline antibiotics residues in milk samples. J Sep Sci. 2021 May;44(10):2121-2130. doi: 10.1002/jssc.202001218. Epub 2021 Apr 9. PMID: 33720499. 2. Do E, Lee HG, Park M, Cho YJ, Kim DH, Park SH, Eun D, Park T, An S, Jung WH. Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta. Mycobiology. 2019 Jun 22;47(2):242-249. doi: 10.1080/12298093.2019.1625175. PMID: 31448144; PMCID: PMC6691833.
In vitro protocol:
1. Nemati M, Farajzadeh MA, Afshar Mogaddam MR. Development of a surfactant-assisted dispersive solid phase extraction using deep eutectic solvent to extract four tetracycline antibiotics residues in milk samples. J Sep Sci. 2021 May;44(10):2121-2130. doi: 10.1002/jssc.202001218. Epub 2021 Apr 9. PMID: 33720499. 2. Do E, Lee HG, Park M, Cho YJ, Kim DH, Park SH, Eun D, Park T, An S, Jung WH. Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta. Mycobiology. 2019 Jun 22;47(2):242-249. doi: 10.1080/12298093.2019.1625175. PMID: 31448144; PMCID: PMC6691833.
In vivo protocol:
TBD
1: Sugiyama M, Ueki T, Ogata S, Itagaki H. Predicting the results of a 24-hr human patch test for surfactants: utility of margin-setting in a reconstructed human epidermis model. J Toxicol Sci. 2019;44(6):393-403. doi: 10.2131/jts.44.393. PMID: 31167989. 2: Machida M, Sano K, Arakawa M, Hayashi M, Awazu S. Effects of surfactants and protease inhibitors on nasal absorption of recombinant human granulocyte colony- stimulating factor (rhG-CSF) in rats. Biol Pharm Bull. 1994 Oct;17(10):1375-8. doi: 10.1248/bpb.17.1375. PMID: 7533020. 3: Combes C, Arnaudis J. Research on the use of surface active substances in the protection against Schistosoma cercariae. Acta Trop. 1982 Mar;39(1):79-84. PMID: 6122366.