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MedKoo Cat#: 462882 | Name: Fuziline
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity. It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline reduces the production of reactive oxygen species and apoptosis induced by isoproterenol in H9c2 rat cardiomyocytes. In vivo, fuziline reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.

Chemical Structure

Fuziline
Fuziline
CAS#80665-72-1

Theoretical Analysis

MedKoo Cat#: 462882

Name: Fuziline

CAS#: 80665-72-1

Chemical Formula: C24H39NO7

Exact Mass: 453.2727

Molecular Weight: 453.58

Elemental Analysis: C, 63.55; H, 8.67; N, 3.09; O, 24.69

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
Fuziline; 15α-Hydroxyneoline; Senbusine C;
IUPAC/Chemical Name
(3S,6S,7R,7aR,8S,9S,10R,11S,11aR,13R,14R)-1-ethyl-10,13-dimethoxy-3-(methoxymethyl)tetradecahydro-11aH-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocine-6,8,11,11a-tetraol
InChi Key
FPECZWKKKKZPPP-WFAXMRCRSA-N
InChi Code
InChI=1S/C24H39NO7/c1-5-25-9-22(10-30-2)7-6-13(26)23-12-8-11-16(27)14(12)24(29,21(28)17(11)31-3)15(20(23)25)18(32-4)19(22)23/h11-21,26-29H,5-10H2,1-4H3/t11-,12+,13-,14+,15?,16-,17+,18-,19+,20?,21-,22-,23?,24+/m0/s1
SMILES Code
O[C@@H]1C2([C@@]([H])([C@](C3)(CC1)COC)[C@H](C4[C@]5([C@H]([C@@H]([C@@H](C[C@]2([H])[C@@H]56)[C@@]6(O)[H])OC)O)O)OC)C4N3CC
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chang N, Gao J, Niu L, Hou Y, Wang X, Jiang M, Bai G. Integrated artificial neural network analysis and functional cell based affinity mass spectrometry for screening a bifunctional activator of Ca2+ and β2AR in aconite. J Pharm Biomed Anal. 2020 Aug 1;190:113506. doi: 10.1016/j.jpba.2020.113506. Epub ahead of print. PMID: 32777733. 2: Zhao L, Sun Z, Yang L, Cui R, Yang W, Li B. Neuropharmacological effects of Aconiti Lateralis Radix Praeparata. Clin Exp Pharmacol Physiol. 2020 Apr;47(4):531-542. doi: 10.1111/1440-1681.13228. Epub 2020 Jan 23. PMID: 31837236. 3: Fan CL, Yao ZH, Ye MN, Fu LL, Zhu GN, Dai Y, Yao XS. Fuziline alleviates isoproterenol-induced myocardial injury by inhibiting ROS-triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway. J Cell Mol Med. 2020 Jan;24(2):1332-1344. doi: 10.1111/jcmm.14803. Epub 2019 Dec 7. PMID: 31811750; PMCID: PMC6991694. 4: Tan G , Wang X , Liu K , Dong X , Liao W , Wu H . Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats. Food Funct. 2018 Nov 14;9(11):5528-5535. doi: 10.1039/c8fo01217b. PMID: 30209468. 5: Tang JF, Zhang SQ, Wang XY, Li WX, He YN, Cao ZX, Zhang DK. [Quality consistency evaluation of Fuzi formula granules using determination of multi- component contents by HPLC-MS/MS method]. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1871-1879. Chinese. doi: 10.19540/j.cnki.cjcmm.20180208.006. PMID: 29902899. 6: Yun WJ, Yao ZH, Fan CL, Qin ZF, Tang XY, Gao MX, Dai Y, Yao XS. Systematic screening and characterization of Qi-Li-Qiang-Xin capsule-related xenobiotics in rats by ultra-performance liquid chromatography coupled with quadrupole time-of- flight tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 15;1090:56-64. doi: 10.1016/j.jchromb.2018.05.014. Epub 2018 May 12. PMID: 29787993. 7: Zhao D, Shi Y, Zhu X, Liu L, Ji P, Long C, Shen Y, Kennelly EJ. Identification of Potential Biomarkers from Aconitum carmichaelii, a Traditional Chinese Medicine, Using a Metabolomic Approach. Planta Med. 2018 Apr;84(6-07):434-441. doi: 10.1055/s-0043-121708. Epub 2017 Oct 26. PMID: 29076119. 8: Huang D, Zhao X, Liu X, Chao R. Determination of Five Aminoalcohol- diterpenoid Alkaloids in the Lateral Root of Aconitum carmichaeli by HPLC-ELSD with SPE. J Chromatogr Sci. 2017 Oct 1;55(9):940-945. doi: 10.1093/chromsci/bmx059. PMID: 28985284. 9: Xu Y, Li Y, Zhang P, Yang B, Wu H, Guo X, Li Y, Zhang Y. Sensitive UHPLC- MS/MS quantitation and pharmacokinetic comparisons of multiple alkaloids from Fuzi- Beimu and single herb aqueous extracts following oral delivery in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 15;1058:24-31. doi: 10.1016/j.jchromb.2017.05.016. Epub 2017 May 15. PMID: 28528229. 10: Zhang DK, Han X, Tan P, Li RY, Niu M, Zhang CE, Wang JB, Yang M, Xiao XH. Establishment of one-step approach to detoxification of hypertoxic aconite based on the evaluation of alkaloids contents and quality. Chin J Nat Med. 2017 Jan;15(1):49-61. doi: 10.1016/S1875-5364(17)30008-0. PMID: 28259253. 11: Zhang Y, Tian D, Huang Y, Li L, Mao J, Tian J, Ding J. Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration. Acta Pharm Sin B. 2016 Nov;6(6):584-592. doi: 10.1016/j.apsb.2016.05.006. Epub 2016 Jun 11. PMID: 27818926; PMCID: PMC5071638. 12: Li P, Lv B, Jiang X, Wang T, Ma X, Chang N, Wang X, Gao X. Identification of NF-κB inhibitors following Shenfu injection and bioactivity-integrated UPLC/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico. J Ethnopharmacol. 2016 Dec 24;194:658-667. doi: 10.1016/j.jep.2016.10.052. Epub 2016 Oct 19. PMID: 27771457. 13: Zhang DK, Han X, Li RY, Niu M, Dong Q, Yang M, Wang JB, Xiao XH. Investigation of the chemical markers for experiential quality evaluation of crude aconite by UHPLC-Q-TOF-MS. J Sep Sci. 2016 Nov;39(22):4281-4289. doi: 10.1002/jssc.201600567. Epub 2016 Oct 10. PMID: 27624993. 14: Sun Q, Cao H, Zhou Y, Wang X, Jiang H, Gong L, Yang Y, Rong R. Qualitative and quantitative analysis of the chemical constituents in Mahuang-Fuzi-Xixin decoction based on high performance liquid chromatography combined with time-of- flight mass spectrometry and triple quadrupole mass spectrometers. Biomed Chromatogr. 2016 Nov;30(11):1820-1834. doi: 10.1002/bmc.3758. Epub 2016 Jul 5. PMID: 27183898. 15: Ji X, Liu H, An C, Wang Y, Zhao H, Zhang Q, Li M, Qi F, Chen Z, Wang X, Wang L. You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis. J Ethnopharmacol. 2016 Jul 1;187:123-33. doi: 10.1016/j.jep.2016.04.025. Epub 2016 Apr 20. PMID: 27106785. 16: Zhang DK, Han X, Li RY, Niu M, Zhao YL, Wang JB, Yang M, Xiao XH. [Analysis on characteristic constituents of crude Aconitum carmichaelii in different regions based on UPLC-Q-TOF-MS]. Zhongguo Zhong Yao Za Zhi. 2016 Feb;41(3):463-469. Chinese. doi: 10.4268/cjcmm20160318. PMID: 28868865. 17: Gong XH, Li Y, Li YX, Yuan A, Zhao MJ, Zhang RQ, Zeng DW, Peng C. Development and Validation of an UPLC-Q-TOF-MS Method for Quantification of Fuziline in Beagle Dog After Intragastric and Intravenous Administration. J Chromatogr Sci. 2016 Mar;54(3):405-12. doi: 10.1093/chromsci/bmv156. Epub 2015 Nov 11. PMID: 26564737. 18: Yang H, Gao W, Liu L, Liu K, Liu EH, Qi LW, Li P. Discovery of characteristic chemical markers for classification of aconite herbs by chromatographic profile and probabilistic neural network. J Pharm Biomed Anal. 2015 Nov 10;115:10-9. doi: 10.1016/j.jpba.2015.06.021. Epub 2015 Jun 23. PMID: 26142559. 19: Yang CL, Huang ZF, Zhang YH, Liu YH, Liu YH, Chen Y, Yi JH. [Effects of steaming and baking on content of alkaloids in Aconite Lateralis Radix (Fuzi)]. Zhongguo Zhong Yao Za Zhi. 2014 Dec;39(24):4798-803. Chinese. PMID: 25898581. 20: Wang HY, Zuo AX, Sun Y, Rao GX. [Chemical constituents of Aconitum brachypodum from Dong-Chuan area]. Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(24):4324-8. Chinese. PMID: 24791539.