MedKoo Cat#: 574737 | Name: Hymenialdisine Analogue #1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hymenialdisine Analogue #1 is the indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations.

Chemical Structure

Hymenialdisine Analogue #1
Hymenialdisine Analogue #1
CAS#693222-51-4

Theoretical Analysis

MedKoo Cat#: 574737

Name: Hymenialdisine Analogue #1

CAS#: 693222-51-4

Chemical Formula: C15H13N5O2

Exact Mass: 295.1069

Molecular Weight: 295.30

Elemental Analysis: C, 61.01; H, 4.44; N, 23.72; O, 10.84

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Synonym
Hymenialdisine Analogue #1; Hymenialdisine Analogue 1
IUPAC/Chemical Name
5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-b]indol-1-one
InChi Key
SMPPSGXPGZSJCP-FLIBITNWSA-N
InChi Code
InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,18H,5-6H2,(H,17,21)(H3,16,19,20,22)/b11-8-
SMILES Code
O=C(C(N1)=C/2C3=C1C=CC=C3)NCCC2=C4N=C(N)NC\4=O
Appearance
Light Yellow to Yellow Solid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 295.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Basati G, Saffari-Chaleshtori J, Abbaszadeh S, Asadi-Samani M, Ashrafi-Dehkordi K. Molecular Dynamics Mechanisms of the Inhibitory Effects of Abemaciclib, Hymenialdisine, and Indirubin on CDK-6. Curr Drug Res Rev. 2019;11(2):135-141. doi:10.2174/2589977511666191018180001 2. Nguyen TN, Tepe JJ. Preparation of hymenialdisine, analogues and their evaluation as kinase inhibitors. Curr Med Chem. 2009;16(24):3122-3143. doi:10.2174/092986709788803015 3. Meijer L, Thunnissen AM, White AW, et al. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol. 2000;7(1):51-63. doi:10.1016/s1074-5521(00)00063-6