HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6). Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones. HPOB reduces the growth, but not the viability, of normal and transformed cells. It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin. HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft.
MedKoo Cat#: 574735
Name: HPOB
CAS#: 1429651-50-2
Chemical Formula: C17H18N2O4
Exact Mass: 314.1267
Molecular Weight: 314.34
Elemental Analysis: C, 64.96; H, 5.77; N, 8.91; O, 20.36
The following data is based on the product molecular weight 314.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
