Synonym
Timefuronum; Timefurona; U-56,321;
IUPAC/Chemical Name
4,9-dimethoxy-7-((methylthio)methyl)-5H-furo[3,2-g]chromen-5-one
InChi Key
SWKFRGASPZPNBV-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14O5S/c1-17-12-9-4-5-19-13(9)15(18-2)14-11(12)10(16)6-8(20-14)7-21-3/h4-6H,7H2,1-3H3
SMILES Code
COc(c(OC(CSC)=CC1=O)c1c2OC)c3c2cco3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
306.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Volgushev SA, Kosykh VA, Podrez EA, Novikov DK, Fuki IV, Karpov RS, Repin VS. Vliianie kellina i taĭmfurona na sekretsiiu i katabolizm lipoproteidov kul'tiviruemymi gepatotsitami cheloveka i krolika [The effect of khellin and timefurone on secretion and catabolism of lipoproteins by cultured human and rabbit hepatocytes]. Biokhimiia. 1990 Feb;55(2):346-51. Russian. PMID: 2340318.
2: Stevens TJ, Vidmar TJ, Day CE. Evaluation of timefurone, a new anti- atherosclerotic drug, for its effects on lipoprotein cholesterol in male cynomolgus monkeys fed an atherogenic diet for 18 months. Atherosclerosis. 1985 Sep;56(3):301-11. doi: 10.1016/0021-9150(85)90005-x. PMID: 3863622.
3: Stevens TJ, Schurr PE, Gammill RB, Day CE. Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male SEA Japanese quail and rats. Atherosclerosis. 1985 Sep;56(3):313-21. doi: 10.1016/0021-9150(85)90006-1. PMID: 3863623.
4: Stevens TJ, Phillips WA, Day CE. Comparative effects of khellin and timefurone on serum parameters in normal male cynomolgus monkeys. J Med Primatol. 1985;14(5):255-62. PMID: 4057238.
