Synonym
(S)-Glycyl-H-1152 hydrochloride; (S)-Glycyl-H-1152 HCl; (S)-Glycyl-H 1152 HCl; (S)-Glycyl-H1152 HCl;Rho Kinase Inhibitor IV
IUPAC/Chemical Name
(S)-2-amino-1-(3-methyl-4-((4-methylisoquinolin-5-yl)sulfonyl)-1,4-diazepan-1-yl)ethan-1-one dihydrochloride
InChi Key
ILDBNQGLZFSHQZ-UTLKBRERSA-N
InChi Code
InChI=1S/C18H24N4O3S.2ClH/c1-13-10-20-11-15-5-3-6-16(18(13)15)26(24,25)22-8-4-7-21(12-14(22)2)17(23)9-19;;/h3,5-6,10-11,14H,4,7-9,12,19H2,1-2H3;2*1H/t14-;;/m0../s1
SMILES Code
O=S(N1[C@@H](C)CN(C(CN)=O)CCC1)(C2=CC=CC3=C2C(C)=CN=C3)=O.[H]Cl.[H]Cl
Appearance
A solution in methanol
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
449.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Olson, M.F. Applications for ROCK kinase inhibition. Current Opinion in Cell Biology 20, 242-248 (2008).
2. Narumiya, S., Tanji, M., and Ishizaki, T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Reviews 28, 65-76 (2009).
3. Watanabe, K., Ueno, M., Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology 25(6), 681-686 (2007).
4. Tamura, M., Nakao, H., Yoshizaki, H., et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochimica et Biophysica Acta 1754, 245-252 (2005).
5. Ishizaki, T., Uehata, M., Tamechika, I., et al. Pharmacological properties of Y-27632, a specific inhibitor of Rho-associated kinases. Molecular Pharmacology 57, 976-983 (2000).
-Glycyl-H-1152 hydrochloride3344.jpg "(S)-Glycyl-H-1152 hydrochloride")
