GKL-003 | CAS# 1445801-61-5 | Inhibitor

MedKoo Cat#: 574723 | Name: GKL-003

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GKL-003 is an inhibitor of Bacterial Transcription Initiation Complex formation.

Chemical Structure

GKL-003

CAS#1445801-61-5

Theoretical Analysis

MedKoo Cat#: 574723

Name: GKL-003

CAS#: 1445801-61-5

Chemical Formula: C34H28Cl2N4O6

Exact Mass: 658.1386

Molecular Weight: 659.52

Elemental Analysis: C, 61.92; H, 4.28; Cl, 10.75; N, 8.50; O, 14.56

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks
25mg	USD 1,250.00	2 Weeks

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Synonym

GKL003; GKL-003; GKL 003

IUPAC/Chemical Name

3-(4-Chlorophenyl)-N'-(3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole-7-carbonyl)-4,6-dimethoxy-1H-indole-7-carbohydrazide

InChi Key

VBILODCXAJTPGG-UHFFFAOYSA-N

InChi Code

InChI=1S/C34H28Cl2N4O6/c1-43-23-13-25(45-3)29(31-27(23)21(15-37-31)17-5-9-19(35)10-6-17)33(41)39-40-34(42)30-26(46-4)14-24(44-2)28-22(16-38-32(28)30)18-7-11-20(36)12-8-18/h5-16,37-38H,1-4H3,(H,39,41)(H,40,42)

SMILES Code

O=C(C1=C(OC)C=C(OC)C2=C1NC=C2C3=CC=C(Cl)C=C3)NNC(C4=C(OC)C=C(OC)C5=C4NC=C5C6=CC=C(Cl)C=C6)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

GKL-003 is an inhibitor of Bacterial Transcription Initiation Complex formation.

In vitro activity:

This study has identified the region of RNAP to which these compounds bind and demonstrate that one compound, GKL003, has an inhibition constant in the low nanomolar range. This compound has activity against both Gram-positive and -negative organisms, including a community acquired methicillin-resistant strain of the major pathogen Staphylococcus aureus. Reference: ACS Chem Biol. 2013 Sep 20;8(9):1972-80. https://pubmed.ncbi.nlm.nih.gov/23751807/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 659.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Ma C, Yang X, Kandemir H, Mielczarek M, Johnston EB, Griffith R, Kumar N, Lewis PJ. Inhibitors of bacterial transcription initiation complex formation. ACS Chem Biol. 2013 Sep 20;8(9):1972-80. doi: 10.1021/cb400231p. Epub 2013 Jul 5. PMID: 23751807.

In vitro protocol:

In vivo protocol:

TBD

1. Ma C, Yang X, Kandemir H, et al. Inhibitors of bacterial transcription initiation complex formation. ACS Chem Biol. 2013;8(9):1972-1980. doi:10.1021/cb400231p