MedKoo Cat#: 574722 | Name: (R)-Gyramide A hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity but does not affect the closely related enzyme topoisomerase IV.

Chemical Structure

(R)-Gyramide A hydrochloride
(R)-Gyramide A hydrochloride
CAS#1793050-70-0

Theoretical Analysis

MedKoo Cat#: 574722

Name: (R)-Gyramide A hydrochloride

CAS#: 1793050-70-0

Chemical Formula: C21H28ClFN2O3S

Exact Mass: 442.1493

Molecular Weight: 442.97

Elemental Analysis: C, 56.94; H, 6.37; Cl, 8.00; F, 4.29; N, 6.32; O, 10.84; S, 7.24

Price and Availability

Size Price Availability Quantity
1mg USD 250.00 2 Weeks
5mg USD 400.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 1,000.00 2 Weeks
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Related CAS #
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Synonym
(R)-534F6; (R)-Gyramide A hydrochloride, (R)-Gyramide A HCl
IUPAC/Chemical Name
5-fluoro-2-methyl-N-[(3R)-1-[[4-(1-methylethoxy)phenyl]methyl]-3-pyrrolidinyl]-benzenesulfonamide, monohydrochloride
InChi Key
LLHBXQVGBTVEDP-FSRHSHDFSA-N
InChi Code
InChI=1S/C21H27FN2O3S.ClH/c1-15(2)27-20-8-5-17(6-9-20)13-24-11-10-19(14-24)23-28(25,26)21-12-18(22)7-4-16(21)3;/h4-9,12,15,19,23H,10-11,13-14H2,1-3H3;1H/t19-;/m1./s1
SMILES Code
O=S(C1=CC(F)=CC=C1C)(N[C@H]2CN(CC3=CC=C(OC(C)C)C=C3)CC2)=O.[H]Cl
Appearance
A crystalline solid
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 442.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Foss, M.H., Hurley, K.A., Sorto, N.A., et al. N-Benzyl-3-sulfonamidopyrrolidines are a new class of bacterial DNA gyrase inhibitors. ACS Med.Chem.Lett. 2, 289-292 (2011). 2. Rajendram, M., Hurley, K.A., Foss, M.H., et al. Gyramides prevent bacterial growth by inhibiting DNA gyrase and altering chromosome topology. ACS Chemical Biology 9(6), 1312-1319 (2014).