GW-610 | CAS# 872726-44-8 | Antiproliferative

MedKoo Cat#: 574719 | Name: GW-610

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW-610 is an antiproliferative agent and tyrosine kinase inhibitor.

Chemical Structure

GW-610

CAS#872726-44-8

Theoretical Analysis

MedKoo Cat#: 574719

Name: GW-610

CAS#: 872726-44-8

Chemical Formula: C15H12FNO2S

Exact Mass: 289.0573

Molecular Weight: 289.32

Elemental Analysis: C, 62.27; H, 4.18; F, 6.57; N, 4.84; O, 11.06; S, 11.08

Price and Availability

Size	Price	Availability
10mg	USD 400.00	2 Weeks
25mg	USD 750.00	2 Weeks
50mg	USD 1,250.00	2 Weeks

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Synonym

GW-610; GW610; GW 610; NSC-721648; NSC721648; NSC 721648;

IUPAC/Chemical Name

2-(3,4-dimethoxyphenyl)-5-fluorobenzo[d]thiazole

InChi Key

ZRLSVQBGBBYEAZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H12FNO2S/c1-18-12-5-3-9(7-13(12)19-2)15-17-11-8-10(16)4-6-14(11)20-15/h3-8H,1-2H3

SMILES Code

FC1=CC=C(SC(C2=CC=C(OC)C(OC)=C2)=N3)C3=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines.

In vitro activity:

5F-203 exhibited potent activity against breast cancer cells, whereas GW-610 was effective against both breast and colorectal cancer cells. CYP1A1 was induced in both breast cancer and CRC cells, while CYP2S1 and CYP2W1 were selectively induced in breast cancer cells only following treatment with 5F-203 or GW-610. Depletion of CYP1A1 abrogated the sensitivity of breast cancer and CRC cells to 5F-203 and GW-610. Reference: Mol Cancer Ther. 2011 Oct;10(10):1982-92. https://pubmed.ncbi.nlm.nih.gov/21831963/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	34.56
	DMF:PBS (pH 7.2) (1:3)	0.3	0.86
	DMSO	9.5	32.84

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 289.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Tan BS, Tiong KH, Muruhadas A, Randhawa N, Choo HL, Bradshaw TD, Stevens MF, Leong CO. CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Mol Cancer Ther. 2011 Oct;10(10):1982-92. doi: 10.1158/1535-7163.MCT-11-0391. Epub 2011 Aug 10. PMID: 21831963. 2. Mortimer CG, Wells G, Crochard JP, Stone EL, Bradshaw TD, Stevens MF, Westwell AD. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem. 2006 Jan 12;49(1):179-85. doi: 10.1021/jm050942k. PMID: 16392802.

In vitro protocol:

In vivo protocol:

TBD

1. Mortimer CG, Wells G, Crochard JP, Stone EL, Bradshaw TD, Stevens MF, Westwell AD. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem.2006 Jan 12;49(1):179-85.