Synonym
U-88204; U-88204E;
IUPAC/Chemical Name
(1H-indol-2-yl)(4-(3-(isopropylamino)pyridin-2-yl)piperazin-1-yl)methanone
InChi Key
ASOMNDIOOKDVDC-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25N5O/c1-15(2)23-18-8-5-9-22-20(18)25-10-12-26(13-11-25)21(27)19-14-16-6-3-4-7-17(16)24-19/h3-9,14-15,23-24H,10-13H2,1-2H3
SMILES Code
CC(C)NC1=CC=CN=C1N(CC2)CCN2C(C3=CC4=CC=CC=C4N3)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
363.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dueweke TJ, Kézdy FJ, Waszak GA, Deibel MR Jr, Tarpley WG. The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem. 1992 Jan 5;267(1):27-30. PMID: 1370445.
2: Vasudevachari MB, Battista C, Lane HC, Psallidopoulos MC, Zhao B, Cook J, Palmer JR, Romero DL, Tarpley WG, Salzman NP. Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors. Virology. 1992 Sep;190(1):269-77. doi: 10.1016/0042-6822(92)91213-e. PMID: 1382341.
3: Balzarini J, Karlsson A, Meichsner C, Paessens A, Riess G, De Clercq E, Kleim JP. Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720. J Virol. 1994 Dec;68(12):7986-92. doi: 10.1128/JVI.68.12.7986-7992.1994. PMID: 7525984; PMCID: PMC237261.
4: Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Palmer JR, Thomas RC, Aristoff PA, et al. Kinetic studies with the non- nucleoside HIV-1 reverse transcriptase inhibitor U-88204E. Biochemistry. 1993 Jul 6;32(26):6548-54. doi: 10.1021/bi00077a008. PMID: 7687145.
