MedKoo Cat#: 408116 | Name: 5-Hydroxymethyldeoxyuridine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

5-Hydroxymethyldeoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).

Chemical Structure

5-Hydroxymethyldeoxyuridine
5-Hydroxymethyldeoxyuridine
CAS#5116-24-5

Theoretical Analysis

MedKoo Cat#: 408116

Name: 5-Hydroxymethyldeoxyuridine

CAS#: 5116-24-5

Chemical Formula: C10H14N2O6

Exact Mass: 258.0852

Molecular Weight: 258.23

Elemental Analysis: C, 46.51; H, 5.46; N, 10.85; O, 37.17

Price and Availability

Size Price Availability Quantity
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
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Synonym
5-Hydroxymethyldeoxyuridine; α-Hydroxythymidine; 2'-Deoxy-5-(hydroxymethyl)uridine; 5-Hydroxymethyl-2'-deoxyuridine
IUPAC/Chemical Name
Uridine, 2'-deoxy-5-(hydroxymethyl)
InChi Key
IPAVKOYJGUMINP-XLPZGREQSA-N
InChi Code
InChI=1S/C10H14N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2,6-8,13-15H,1,3-4H2,(H,11,16,17)/t6-,7+,8+/m0/s1
SMILES Code
OC[C@@H]1[C@H](C[C@H](N2C(NC(C(CO)=C2)=O)=O)O1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 258.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Meldrum JB, Gupta VS, Lowes NR, Paterson AR. Toxicologic and antitumor studies on 5-hydroxymethyldeoxyuridine. Toxicol Appl Pharmacol. 1985 Jul;79(3):423-35. doi: 10.1016/0041-008x(85)90140-1. PMID: 4035687. 2: Bilimoria MH, Gupta SV. Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2'-deoxyuridine analogs in the Ames Salmonella/microsome test. Mutat Res. 1986 Mar;169(3):123-7. doi: 10.1016/0165-1218(86)90091-1. PMID: 3512995. 3: Kirsh ME, Cutler RG, Hartman PE. Absence of deoxyuridine and 5-hydroxymethyldeoxyuridine in the DNA from three tissues of mice of various ages. Mech Ageing Dev. 1986 Jun;35(1):71-7. doi: 10.1016/0047-6374(86)90067-9. PMID: 2426529. 4: Meldrum JB, Gupta VS, Saunders JR. Cell culture studies on the antiviral activity of ether derivatives of 5-hydroxymethyldeoxyuridine. Antimicrob Agents Chemother. 1974 Oct;6(4):393-6. doi: 10.1128/AAC.6.4.393. PMID: 4157332; PMCID: PMC444658. 5: Maldonado-Rodríguez R, Espinosa-Lara M, Peña Valdivia B. Estudio comparativo del efecto de 5-bromodesoxiuridina y de 5-hidroximetildesoxiuridina sobre el desarrollo de Escherichia coli auxotrofa a timidina [Comparative study of the effect of 5-bromodeoxyuridine and 5-hydroxymethyldeoxyuridine on the development of Escherichia coli auxotrophic for thymidine]. Rev Latinoam Microbiol. 1981 Oct-Dec;23(4):229-34. Spanish. PMID: 6755601. 6: Lockshin A, Meshcherikova VV. Selektivnaia toksichnost' 5-gidroksimetildezoksiuridina dlia kletok adenokartsinomy tolstoĭ kishki cheloveka [The selective toxicity of 5-hydroxymethyldeoxyuridine for the cells of human adenocarcinoma of the large intestine]. Vopr Onkol. 1989;35(11):1327-32. Russian. PMID: 2609523. 7: Lewis HL, Muhleman DR, Ward JF. Serologic assay of DNA base damage. I. 5-Hydroxymethyldeoxyuridine, a radiation product of thymidine. Radiat Res. 1978 Aug;75(2):305-16. PMID: 568811.