Gomisin G | CAS# 62956-48-3 | UDP-glucuronosyltransferases inhibitor

MedKoo Cat#: 574712 | Name: Gomisin G

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gomisin G is a UDP-glucuronosyltransferases inhibitor and drug candidate for the treatment of cardiovascular disease.

Chemical Structure

Gomisin G

CAS#62956-48-3

Theoretical Analysis

MedKoo Cat#: 574712

Name: Gomisin G

CAS#: 62956-48-3

Chemical Formula: C30H32O9

Exact Mass: 536.2046

Molecular Weight: 536.58

Elemental Analysis: C, 67.15; H, 6.01; O, 26.84

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks
25mg	USD 1,250.00	2 Weeks

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Synonym

Gomisin G; (-)-Gomisin G

IUPAC/Chemical Name

(6S,7S,8S)-7-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-8-yl benzoate

InChi Key

OFDWKHIQKPKRKY-DSASHONVSA-N

InChi Code

InChI=1S/C30H32O9/c1-16-12-18-13-20(33-3)24(34-4)26(35-5)22(18)23-19(14-21-25(27(23)36-6)38-15-37-21)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3/t16-,28-,30-/m0/s1

SMILES Code

COC1=C(OCO2)C2=CC([C@H](OC(C3=CC=CC=C3)=O)[C@](O)(C)[C@@H](C)C4)=C1C(C4=CC(OC)=C5OC)=C5OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively.

In vitro activity:

To determine whether Gomisin G affects colon cancer cells, this study investigated its effect on the viability of LoVo cells using the MTT assay. Treatment with Gomisin G significantly inhibited the growth of LoVo cells in a dose and time dependent manner (Fig. 1A). Reference: Biomol Ther (Seoul). 2019 Mar 1;27(2):210-215. https://pubmed.ncbi.nlm.nih.gov/29902863/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	50.0	93.18

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 536.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Lee Y, Kwon HJ. Gomisin G Suppresses the Growth of Colon Cancer Cells by Attenuation of AKT Phosphorylation and Arrest of Cell Cycle Progression. Biomol Ther (Seoul). 2019 Mar 1;27(2):210-215. doi: 10.4062/biomolther.2018.054. PMID: 29902863; PMCID: PMC6430222. 2. Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Kwon HJ. Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1. Biomol Ther (Seoul). 2018 May 1;26(3):322-327. doi: 10.4062/biomolther.2017.235. Erratum in: Biomol Ther (Seoul). 2018 Sep 1;26(5):520. Lim Y [corrected to Lim page Y]. PMID: 29587339; PMCID: PMC5933900.

In vitro protocol:

In vivo protocol:

TBD

1. Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Kwon HJ. Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1 [published correction appears in Biomol Ther (Seoul). 2018 Sep 1;26(5):520. Lim Y [corrected to Lim page Y]]. Biomol Ther (Seoul). 2018;26(3):322-327. doi:10.4062/biomolther.2017.235 2. Zhao J, Sun T, Wu JJ, et al. Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis. Fitoterapia. 2017;119:26-31. doi:10.1016/j.fitote.2017.03.010