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MedKoo Cat#: 462828 | Name: Hederasaponin B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hederasaponin B is a triterpene saponin that has been found in H. helix and has antiviral and antioxidant activities. It inhibits the cytopathic effect induced by the enterovirus 71 genotypes C3 and C4a, as well as reduces expression of the viral structural capsid protein VP2, in Vero cells. Hederasaponin B inhibits superoxide generation in human neutrophils.

Chemical Structure

Hederasaponin B
Hederasaponin B
CAS#36284-77-2

Theoretical Analysis

MedKoo Cat#: 462828

Name: Hederasaponin B

CAS#: 36284-77-2

Chemical Formula: C59H96O25

Exact Mass: 1204.6241

Molecular Weight: 1205.39

Elemental Analysis: C, 58.79; H, 8.03; O, 33.18

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
25mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
Hederacoside B; Hederacoside-B; Hederagenin B; Hederagenin-B;
IUPAC/Chemical Name
(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
InChi Key
NVSLBOBPSCMMSO-BVLVEXITSA-N
InChi Code
InChI=1S/C59H96O25/c1-24-34(62)38(66)42(70)49(77-24)82-46-29(21-60)79-48(45(73)41(46)69)76-23-30-37(65)40(68)44(72)51(80-30)84-53(74)59-18-16-54(3,4)20-27(59)26-10-11-32-56(7)14-13-33(55(5,6)31(56)12-15-58(32,9)57(26,8)17-19-59)81-52-47(36(64)28(61)22-75-52)83-50-43(71)39(67)35(63)25(2)78-50/h10,24-25,27-52,60-73H,11-23H2,1-9H3/t24-,25-,27-,28-,29+,30+,31-,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,56-,57+,58+,59-/m0/s1
SMILES Code
CC1(CC[C@@]2(CC[C@]3([C@](C)(CC[C@]4([H])[C@@]5(CC[C@H](O[C@@H]6OC[C@@H]([C@@H]([C@H]6O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)O)O)C4(C)C)C)[C@@]5(CC=C3[C@@]2(C1)[H])[H])C)C(O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O[C@H]%10[C@@H]([C@@H]([C@H]([C@@H](O%10)C)O)O)O)CO)O)O)O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,205.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Song J, Yeo SG, Hong EH, Lee BR, Kim JW, Kim J, Jeong H, Kwon Y, Kim H, Lee S, Park JH, Ko HJ. Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a. Biomol Ther (Seoul). 2014 Jan;22(1):41-6. doi: 10.4062/biomolther.2013.108. PMID: 24596620; PMCID: PMC3936428. 2: Liu J, Yang X, Li L, Zhang Q, Zhang Z, Zhang X, Zhao Y, Yu M, Yu Z. A rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of hederasaponin B in rat plasma: Application to a pharmacokinetic study. Asian J Pharm Sci. 2017 Jul;12(4):363-369. doi: 10.1016/j.ajps.2016.09.001. Epub 2016 Sep 22. PMID: 32104347; PMCID: PMC7032190. 3: Liu Q, Zhu XZ, Feng RB, Liu Z, Wang GY, Guan XF, Ou GM, Li YL, Wang Y, Li MM, Ye WC. Crude triterpenoid saponins from Anemone flaccida (Di Wu) exert anti- arthritic effects on type II collagen-induced arthritis in rats. Chin Med. 2015 Jul 25;10:20. doi: 10.1186/s13020-015-0052-y. PMID: 26213566; PMCID: PMC4515010. 4: Chen X, Lu J, He W, Chi H, Yamashita K, Manabe M, Kodama H. Antiperoxidation activity of triterpenoids from rhizome of Anemone raddeana. Fitoterapia. 2009 Mar;80(2):105-11. doi: 10.1016/j.fitote.2008.11.003. Epub 2008 Nov 19. PMID: 19084054. 5: Kizu H, Shimana H, Tomimori T. Studies on the constituents of Clematis species. VI. The constituents of Clematis stans Sieb. et Zucc. Chem Pharm Bull (Tokyo). 1995 Dec;43(12):2187-94. doi: 10.1248/cpb.43.2187. PMID: 8582022. 6: Wua H, Yang Z, Wang Q, Zhub N, Xub X, Zou Q, Tang Y. A New Cytotoxic Cyclolanostane Triterpenoid Xyloside from Souliea vaginata. Nat Prod Commun. 2017 Feb;12(2):229-232. PMID: 30428218. 7: Yu M, Shin YJ, Kim N, Yoo G, Park S, Kim SH. Determination of saponins and flavonoids in ivy leaf extracts using HPLC-DAD. J Chromatogr Sci. 2015 Apr;53(4):478-83. doi: 10.1093/chromsci/bmu068. Epub 2014 Jun 30. PMID: 24981979. 8: Lee KJ, Song K, Song DY, Kim YS. Application of linear gradient elution in countercurrent chromatography for the separation of triterpenoid saponins from the roots of Pulsatilla koreana Nakai. J Sep Sci. 2017 Jul;40(13):2810-2818. doi: 10.1002/jssc.201700100. Epub 2017 Jun 19. PMID: 28544207. 9: Jiang W, Li W, Han L, Liu L, Zhang Q, Zhang S, Nikaido T, Koike K. Biologically active triterpenoid saponins from Acanthopanax senticosus. J Nat Prod. 2006 Nov;69(11):1577-81. doi: 10.1021/np060195+. PMID: 17125224. 10: Majester-Savornin B, Elias R, Diaz-Lanza AM, Balansard G, Gasquet M, Delmas F. Saponins of the ivy plant, Hedera helix, and their leishmanicidic activity. Planta Med. 1991 Jun;57(3):260-2. doi: 10.1055/s-2006-960086. PMID: 1896525. 11: Han LT, Li J, Huang F, Yu SG, Fang NB. Triterpenoid saponins from Anemone flaccida induce apoptosis activity in HeLa cells. J Asian Nat Prod Res. 2009;11(2):122-7. doi: 10.1080/10286020802573818. PMID: 19219723. 12: Hu X, Liu M, Liu Y, Zhang J, Tang Y, Pei H, Liu H, Chen S, Song C, Hu Z. A two-step approach for systematic identification and quality evaluation of wild and introduced Anemone flaccida Fr. Schmidt (Di Wu) based on DNA barcode and UPLC-QTOF-MS/MS. Anal Bioanal Chem. 2020 Mar;412(8):1807-1816. doi: 10.1007/s00216-020-02426-w. Epub 2020 Feb 6. PMID: 32025771.

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