SJF 1521 | CAS# 2230821-40-4 | EGFR degrader

MedKoo Cat#: 462819 | Name: SJF 1521

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SJF 1521 is a selective EGFR Degrader. It induces degradation of EGFR in OVCAR8 cells.

Chemical Structure

SJF 1521

CAS#2230821-40-4

Theoretical Analysis

MedKoo Cat#: 462819

Name: SJF 1521

CAS#: 2230821-40-4

Chemical Formula: C57H61ClFN7O9S

Exact Mass: 1073.3924

Molecular Weight: 1074.66

Elemental Analysis: C, 63.71; H, 5.72; Cl, 3.30; F, 1.77; N, 9.12; O, 13.40; S, 2.98

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 750.00	2 Weeks

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Related CAS #

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Synonym

SJF 1521; SJF-1521; SJF1521;

IUPAC/Chemical Name

(2S,4R)-1-((S)-2-(tert-butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChi Key

XZNORRXEBCTXPB-KHBXAZQSSA-N

InChi Code

InChI=1S/C57H61ClFN7O9S/c1-36-52(76-35-63-36)40-10-8-37(9-11-40)30-60-55(69)49-29-44(67)31-66(49)56(70)53(57(2,3)4)65-51(68)33-73-23-22-71-20-21-72-24-25-74-45-16-12-39(13-17-45)41-14-18-48-46(27-41)54(62-34-61-48)64-43-15-19-50(47(58)28-43)75-32-38-6-5-7-42(59)26-38/h5-19,26-28,34-35,44,49,53,67H,20-25,29-33H2,1-4H3,(H,60,69)(H,65,68)(H,61,62,64)/t44-,49+,53-/m1/s1

SMILES Code

CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(COCCOCCOCCOC4=CC=C(C=C4)C5=CC6=C(C=C5)N=CN=C6NC7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7)=O)C(C)(C)C)=O)=O)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SJF 1521 induces degradation of EGFR in OVCAR8 cells. It exhibits selectivity for EGFR, including mutant forms, over HER2.

In vitro activity:

To be determined

In vivo activity:

To be determined

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	107.5	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 1,074.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.