Synonym
Glycogen Phosphorylase Inhibitor; GlycogenPhosphorylaseInhibitor; Glycogen phosphorylase-IN-1; GPI
IUPAC/Chemical Name
2-chloro-4,5-difluoro-N-[[[2-methoxy-5-[[(methylamino)carbonyl]amino]phenyl]amino]carbonyl]-benzamide
InChi Key
ROJNYKZWTOHRNU-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)
SMILES Code
FC1=C(F)C=C(C(NC(NC2=C(OC)C=CC(NC(NC)=O)=C2)=O)=O)C(Cl)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
An inhibitor of glycogen phosphorylase.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
5.0 |
12.11 |
| DMSO |
5.0 |
12.11 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
412.78
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1. Klabunde, T., Wendt, K.U., Kadereit, D., et al. Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Journal of Medicinal Chemistry 48(20), 6178-6193 (2005).
2. Cheng, A., Zhang, M., Gentry, M.S., et al. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori’s disease. Genes & Development 21(19), 2399-2409 (2007).
3. Agathocleous, M., Love, N.K., Randlett, O., et al. Metabolic differentiation in retinal cells. Nature Cell Biology 14(8), 859-864 (2012).
4. Arrizabalaga, O., Lacerda, H.M., Zubiaga, A.M., et al. Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation. The Journal of Biological Chemisty 287(15), 11878-11890 (2012).
