Synonym
NSC 121234; NSC 121234; NSC 121234; Pyracrimycin A; Desdanine;
IUPAC/Chemical Name
(E)-3-(3,4-dihydro-2H-pyrrol-5-yl)acrylamide
InChi Key
SJFPWBFXBOZGTB-ONEGZZNKSA-N
InChi Code
InChI=1S/C7H10N2O/c8-7(10)4-3-6-2-1-5-9-6/h3-4H,1-2,5H2,(H2,8,10)/b4-3+
SMILES Code
NC(/C=C/C1=NCCC1)=O
Purity
>90% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
138.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Takahashi S, Nakajima M, Ikeda Y, Kondo S, Hamada M. A new antibiotic, cyclamidomycin. J Antibiot (Tokyo). 1971 Dec;24(12):902-3. doi: 10.7164/antibiotics.24.902. PMID: 5140536.
2: Saeki T, Hori M, Umezawa H. Cyclamidomycin (desdanine), an inhibitor of nucleoside diphosphokinase of Escherichia coli. J Antibiot (Tokyo). 1972 Jun;25(6):343-9. doi: 10.7164/antibiotics.25.343. PMID: 4568012.
3: Argoudelis AD, Hoeksema H, Whaley HA. Identity of desdanine pyracrimycin A and cyclamidomycin. J Antibiot (Tokyo). 1972 Jul;25(7):432-3. doi: 10.7164/antibiotics.25.432. PMID: 4661099.
4: Nielsen JB, Gren T, Mohite OS, Jørgensen TS, Klitgaard AK, Mourched AS, Blin K, Oves-Costales D, Genilloud O, Larsen TO, Tanner D, Weber T, Gotfredsen CH, Charusanti P. Identification of the Biosynthetic Gene Cluster for Pyracrimycin A, an Antibiotic Produced by Streptomyces sp. ACS Chem Biol. 2022 Sep 16;17(9):2411-2417. doi: 10.1021/acschembio.2c00480. Epub 2022 Aug 30. PMID: 36040247.
5: Coronelli C, Tamoni G, Beretta G, Lancini GC. Production, isolation and properties of pyracrimycin A, a new antibiotic from Streptomyces eridani N. SP. J Antibiot (Tokyo). 1971 Aug;24(8):491-6. doi: 10.7164/antibiotics.24.491. PMID: 4937286.
6: Coronelli C, Vigevani A, Cavalleri B, Gallo GG. Structure determination of pyracrimycin A, a new antibiotic substance. J Antibiot (Tokyo). 1971 Aug;24(8):497-502. doi: 10.7164/antibiotics.24.497. PMID: 5092784.
7: Cavalleri B, Volpe G, Pallanza R. Su alcuni composti correlati alla piracrimicina A [Some compounds correlated to pyracrimycin A]. Farmaco Sci. 1975 Feb;30(2):110-21. Italian. PMID: 1123033.
