N-Demethylclindamycin | CAS#22431-45-4

MedKoo Cat#: 462809 | Name: N-Demethylclindamycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

N-Demethylclindamycin is a biochemical for proteomics research.

Chemical Structure

N-Demethylclindamycin

CAS#22431-45-4

Theoretical Analysis

MedKoo Cat#: 462809

Name: N-Demethylclindamycin

CAS#: 22431-45-4

Chemical Formula: C17H31ClN2O5S

Exact Mass: 410.1642

Molecular Weight: 410.95

Elemental Analysis: C, 49.69; H, 7.60; Cl, 8.63; N, 6.82; O, 19.47; S, 7.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

N-Demethylclindamycin; U 26727A; U26727A; U-26727A; UNII-0C0YZC7W4S

IUPAC/Chemical Name

(2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-4-propylpyrrolidine-2-carboxamide

InChi Key

HDBHHHCDEYATPY-MHXMMLMNSA-N

InChi Code

InChI=1S/C17H31ClN2O5S/c1-4-5-9-6-10(19-7-9)16(24)20-11(8(2)18)15-13(22)12(21)14(23)17(25-15)26-3/h8-15,17,19,21-23H,4-7H2,1-3H3,(H,20,24)/t8-,9+,10-,11+,12-,13+,14+,15+,17+/m0/s1

SMILES Code

CCC[C@H]1CN[C@H](C(N[C@@H]([C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C)=O)C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 410.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gatti G, Malena M, Casazza R, Borin M, Bassetti M, Cruciani M. Penetration of clindamycin and its metabolite N-demethylclindamycin into cerebrospinal fluid following intravenous infusion of clindamycin phosphate in patients with AIDS. Antimicrob Agents Chemother. 1998 Nov;42(11):3014-7. doi: 10.1128/AAC.42.11.3014. PMID: 9797245; PMCID: PMC105985. 2: Argoudelis AD, Coats JH, Magerlein BJ. Microbial transformation of antibiotics. VII. Hydroxymethylation of N-demethylclindamycin. J Antibiot (Tokyo). 1972 Mar;25(3):191-3. doi: 10.7164/antibiotics.25.191. PMID: 5034816. 3: Lenarduzzi T, Langston C, Ross MK. Pharmacokinetics of clindamycin administered orally to pigeons. J Avian Med Surg. 2011 Dec;25(4):259-65. doi: 10.1647/2010-038.1. PMID: 22458181. 4: Gilbertson TJ, Stryd RP. Radioimmunoassay for clindamycin. Clin Chem. 1976 Jun;22(6):828-31. PMID: 1277468. 5: Szultka-Mlynska M, Pomastowski P, Buszewski B. Application of solid phase microextraction followed by liquid chromatography-mass spectrometry in the determination of antibiotic drugs and their metabolites in human whole blood and tissue samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 1;1086:153-165. doi: 10.1016/j.jchromb.2018.04.013. Epub 2018 Apr 12. PMID: 29677683. 6: Alpers DH, Grimme N. Effect ob broad-spectrum antibiotics on in vitro synthesis of DNA in the rabbit colon. J Infect Dis. 1978 Jun;137(6):756-63. doi: 10.1093/infdis/137.6.756. PMID: 659921.